Contents

Research Articles

• Primary cilia defects causing mitral valve prolapse

  By Katelynn A. Toomer, Mengyao Yu, Diana Fulmer, Lilong Guo, Kelsey S. Moore, Reece Moore, Ka’la D. Drayton, Janiece Glover, Neal Peterson, Sandra Ramos-Ortiz, Alex Drohan, Breiona J. Catching, Rebecca Stairley, Andy Wessels, Joshua H. Lipschutz, Francesca N. Delling, Xavier Jeunemaitre, Christian Dina, Ryan L. Collins, Harrison Brand, Michael E. Talkowski, Federica del Monte, Rupak Mukherjee, Alexander Awgulewitsch, Simon Body, Gary Hardiman, E. Starr Hazard, Willian A. da Silveira, Baolin Wang, Maire Leyne, Ronen Durst, Roger R. Markwald, Solena Le Scouarnec, Albert Hagege, Thierry Le Tourneau, Peter Kohl, Eva A. Rog-Zielinska, Patrick T. Ellinor, Robert A. Levine, David J. Milan, Jean-Jacques Schott, Nabila Bouatia-Naji, Susan A. Slaugenhaupt, Russell A. Norris

  Science Translational Medicine22 May 2019 Full AccessRestricted Access

  Genetic variations in primary cilia genes cause defects during valve morphogenesis that can progress to mitral valve prolapse in the adult.

  • Editor's Summary
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• Cardiac glial cells release neurotrophic S100B upon catheter-based treatment of atrial fibrillation

  By Katharina Scherschel, Katja Hedenus, Christiane Jungen, Marc D. Lemoine, Nicole Rübsamen, Marieke W. Veldkamp, Niklas Klatt, Diana Lindner, Dirk Westermann, Simona Casini, Pawel Kuklik, Christian Eickholt, Nikolaj Klöcker, Kalyanam Shivkumar, Torsten Christ, Tanja Zeller, Stephan Willems, Christian Meyer

  Science Translational Medicine22 May 2019 Full AccessRestricted Access

  Catheter ablation for atrial fibrillation induces intracardiac neural damage characterized by glial S100B release, which promotes nerve sprouting.

  • Editor's Summary
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• Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection

  By Zaza M. Ndhlovu, Samuel W. Kazer, Thandeka Nkosi, Funsho Ogunshola, Daniel M. Muema, Gursev Anmole, Shayda A. Swann, Amber Moodley, Krista Dong, Tarylee Reddy, Mark A. Brockman, Alex K. Shalek, Thumbi Ndung’u, Bruce D. Walker

  Science Translational Medicine22 May 2019 Open Access CCBY

  Immediate initiation of antiviral therapy in acute HIV infection results in functional and persistent T cell responses.

  • Editor's Summary
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• Phagocytosis-shielded lentiviral vectors improve liver gene therapy in nonhuman primates

  By Michela Milani, Andrea Annoni, Federica Moalli, Tongyao Liu, Daniela Cesana, Andrea Calabria, Sara Bartolaccini, Mauro Biffi, Fabio Russo, Ilaria Visigalli, Andrea Raimondi, Susannah Patarroyo-White, Douglas Drager, Patrizia Cristofori, Eduard Ayuso, Eugenio Montini, Robert Peters, Matteo Iannacone, Alessio Cantore, Luigi Naldini

  Science Translational Medicine22 May 2019 Full AccessRestricted Access

  Lentiviral vectors with high surface content of CD47 improved gene transfer efficiency to hepatocytes in nonhuman primates.

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• Circulating exosomes derived from transplanted progenitor cells aid the functional recovery of ischemic myocardium

  By Progyaparamita Saha, Sudhish Sharma, Laxminarayana Korutla, Srinivasa Raju Datla, Farnaz Shoja-Taheri, Rachana Mishra, Grace E. Bigham, Malini Sarkar, David Morales, Gregory Bittle, Muthukumar Gunasekaran, Chetan Ambastha, Mir Yasir Arfat, Deqiang Li, Andreas Habertheuer, Robert Hu, Manu O. Platt, Peixin Yang, Michael E. Davis, Prashanth Vallabhajosyula, Sunjay Kaushal

  Science Translational Medicine22 May 2019 Full AccessRestricted Access

  Liquid biopsy of circulating exosomes can be used to monitor recovery of ischemic myocardium after transplanting cardiac progenitor cells.

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