Advances in therapeutic applications of extracellular vesicles

See allHide authors and affiliations

Science Translational Medicine  15 May 2019:
Vol. 11, Issue 492, eaav8521
DOI: 10.1126/scitranslmed.aav8521

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Compose eLetter

Plain text

  • Plain text
    No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g.
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Statement of Competing Interests

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Enter the characters shown in the image.

Vertical Tabs

  • RE: Amniotic Exosomes and Pregnancy
    • Pascal J. Goldschmidt-Clermont, Co-Founder of REGENiSELF, REGENiSELF
    • Other Contributors:
      • Darcy L. DiFede, Chief Operating Officer of REGENiSELF, REGENiSELF
      • Ian A. White, Chief Scientific Officer, REGENiSELF

    In their article, Advances in therapeutic applications of extracellular vesicles, Wiklander et al. provide an instructive review of recent progress made in the field of extracellular vesicles (EVs), and exosomes in particular, they concluded “EVs act as important mediators of intercellular communication that influence both physiological and pathological conditions”. With this eletter, we provide an example of the formidable role of extracellular vesicles in human biology: the case of pregnancy.

    One physiological condition where extracellular vesicles are essential is pregnancy (1). The growth of the human embryo/fetus, in the womb is one of the most rapid situations of tissue growth for humans. It is likely that such growth is facilitated through the paracrine impact of amniosomes, considering the need for massive amounts of information and basic materials (lipids, proteins, complex sugars, nucleic acids, etc.) required to generate a mature human fetus. Actually, the concentration of amniosomes in the amniotic fluid has been reproducibly assessed at 250 billion exosomes per milliliter (1), thus, perhaps, amniotic fluid might be the most exosome rich fluid within the human body.

    It is highly likely that the pregnant mother is also heavily impacted by amniosomes. Amniosomes are small enough (150 nm or less) to pass through the placental barrier. The heart of pregnant women undergoes formidable transformation during pregnancy (2). The stroke volume for a heart...

    Show More
    Competing Interests: The company REGENiSELF is focused on the science of Stem Cell and Extracellular Vesicles for the prevention and treatment of human illnesses.

Stay Connected to Science Translational Medicine