ReviewEXTRACELLULAR VESICLES

Advances in therapeutic applications of extracellular vesicles

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Science Translational Medicine  15 May 2019:
Vol. 11, Issue 492, eaav8521
DOI: 10.1126/scitranslmed.aav8521

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  • RE: Amniotic Exosomes and Pregnancy
    • Pascal J. Goldschmidt-Clermont, Co-Founder of REGENiSELF, REGENiSELF
    • Other Contributors:
      • Darcy L. DiFede, Chief Operating Officer of REGENiSELF, REGENiSELF
      • Ian A. White, Chief Scientific Officer, REGENiSELF

    In their article, Advances in therapeutic applications of extracellular vesicles, Wiklander et al. provide an instructive review of recent progress made in the field of extracellular vesicles (EVs), and exosomes in particular, they concluded “EVs act as important mediators of intercellular communication that influence both physiological and pathological conditions”. With this eletter, we provide an example of the formidable role of extracellular vesicles in human biology: the case of pregnancy.

    One physiological condition where extracellular vesicles are essential is pregnancy (1). The growth of the human embryo/fetus, in the womb is one of the most rapid situations of tissue growth for humans. It is likely that such growth is facilitated through the paracrine impact of amniosomes, considering the need for massive amounts of information and basic materials (lipids, proteins, complex sugars, nucleic acids, etc.) required to generate a mature human fetus. Actually, the concentration of amniosomes in the amniotic fluid has been reproducibly assessed at 250 billion exosomes per milliliter (1), thus, perhaps, amniotic fluid might be the most exosome rich fluid within the human body.

    It is highly likely that the pregnant mother is also heavily impacted by amniosomes. Amniosomes are small enough (150 nm or less) to pass through the placental barrier. The heart of pregnant women undergoes formidable transformation during pregnancy (2). The stroke volume for a heart...

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    Competing Interests: The company REGENiSELF is focused on the science of Stem Cell and Extracellular Vesicles for the prevention and treatment of human illnesses.