Research ArticleRheumatoid Arthritis

HBEGF+ macrophages in rheumatoid arthritis induce fibroblast invasiveness

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Science Translational Medicine  08 May 2019:
Vol. 11, Issue 491, eaau8587
DOI: 10.1126/scitranslmed.aau8587

Article Information

vol. 11 no. 491

PubMed: 
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History: 
  • Received for publication July 21, 2018
  • Resubmitted December 22, 2018
  • Accepted for publication April 19, 2019
  • .

Author Information

  1. David Kuo1,2,*,
  2. Jennifer Ding3,,*,
  3. Ian S. Cohn3,,
  4. Fan Zhang4,5,6,7,
  5. Kevin Wei8,
  6. Deepak A. Rao8,
  7. Cristina Rozo3,
  8. Upneet K. Sokhi3,
  9. Sara Shanaj3,
  10. David J. Oliver3,
  11. Adriana P. Echeverria3,
  12. Edward F. DiCarlo9,
  13. Michael B. Brenner8,
  14. Vivian P. Bykerk3,10,
  15. Susan M. Goodman3,10,
  16. Soumya Raychaudhuri4,5,6,11,
  17. Gunnar Rätsch12,2,
  18. Lionel B. Ivashkiv3,10,13,§ and
  19. Laura T. Donlin3,10,§,||
  1. 1Graduate Program in Physiology, Biophysics and Systems Biology, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.
  2. 2Computational Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA.
  3. 3Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA.
  4. 4Center for Data Sciences, Brigham and Women's Hospital, Boston, MA 02115, USA.
  5. 5Division of Rheumatology and Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  6. 6Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
  7. 7Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  8. 8Division of Rheumatology, Immunology, Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  9. 9Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY 10021, USA.
  10. 10Weill Cornell Medical College, New York, NY 10021, USA.
  11. 11Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Oxford Road, Manchester, UK.
  12. 12Department of Computer Science, Universitätstrasse 6, ETH Zürich, 8092 Zürich, Switzerland
  13. 13Weill Cornell Graduate School of Medical Sciences, New York, NY 10021, USA.
  1. ||Corresponding author. Email: donlinl{at}hss.edu
  • * Co-first authors.

  • Present address: Department of Neurobiology, University of Chicago, Chicago, IL 60637, USA.

  • Present address: Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

  • § Co-senior authors.

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May 201956078011504
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Jul 2019272104102
Aug 20193208571
Sep 20191277056