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Research ArticleCancer
Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma
- View ORCID ProfileLiang Zhang1,*,
- View ORCID ProfileYixin Yao1,*,
- View ORCID ProfileShaojun Zhang2,*,
- View ORCID ProfileYang Liu1,*,
- Hui Guo1,
- View ORCID ProfileMakhdum Ahmed1,
- View ORCID ProfileTaylor Bell1,
- View ORCID ProfileHui Zhang1,
- View ORCID ProfileGuangchun Han2,
- View ORCID ProfileElizabeth Lorence1,
- Maria Badillo1,
- View ORCID ProfileShouhao Zhou3,
- Yuting Sun4,
- View ORCID ProfileM. Emilia Di Francesco4,
- Ningping Feng4,
- Randy Haun5,
- View ORCID ProfileRenny Lan6,
- Samuel G. Mackintosh6,
- Xizeng Mao2,
- Xingzhi Song2,
- View ORCID ProfileJianhua Zhang2,
- Lan V. Pham7,
- View ORCID ProfilePhilip L. Lorenzi8,
- View ORCID ProfileJoseph Marszalek4,
- View ORCID ProfileTim Heffernan4,
- View ORCID ProfileGiulio Draetta2,4,
- View ORCID ProfilePhilip Jones4,
- View ORCID ProfileAndrew Futreal2,
- Krystle Nomie1,
- View ORCID ProfileLinghua Wang2,† and
- View ORCID ProfileMichael Wang1,9,†
- 1Department of Lymphoma and Myeloma, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 2Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 3Department of Biostatistics, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 4Institute for Applied Cancer Science and Center for Co-Clinical Trials, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 5Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
- 6Department of Biochemistry and Molecular Biology and Proteomics Core Facility, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
- 7Department of Hematopathology, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 8Proteomics and Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 9Department of Stem Cell Transplantation and Cellular Therapy, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- ↵†Corresponding author. Email: lwang22{at}mdanderson.org (L.W.); miwang{at}mdanderson.org (M.W.)
↵* These authors contributed equally to this work.
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Science Translational Medicine 08 May 2019:
Vol. 11, Issue 491, eaau1167
DOI: 10.1126/scitranslmed.aau1167
Vol. 11, Issue 491, eaau1167
DOI: 10.1126/scitranslmed.aau1167
Liang Zhang
1Department of Lymphoma and Myeloma, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Yixin Yao
1Department of Lymphoma and Myeloma, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Shaojun Zhang
2Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Yang Liu
1Department of Lymphoma and Myeloma, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Hui Guo
1Department of Lymphoma and Myeloma, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Makhdum Ahmed
1Department of Lymphoma and Myeloma, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Taylor Bell
1Department of Lymphoma and Myeloma, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Hui Zhang
1Department of Lymphoma and Myeloma, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Guangchun Han
2Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Elizabeth Lorence
1Department of Lymphoma and Myeloma, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Maria Badillo
1Department of Lymphoma and Myeloma, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Shouhao Zhou
3Department of Biostatistics, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Yuting Sun
4Institute for Applied Cancer Science and Center for Co-Clinical Trials, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
M. Emilia Di Francesco
4Institute for Applied Cancer Science and Center for Co-Clinical Trials, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Ningping Feng
4Institute for Applied Cancer Science and Center for Co-Clinical Trials, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Randy Haun
5Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Renny Lan
6Department of Biochemistry and Molecular Biology and Proteomics Core Facility, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Samuel G. Mackintosh
6Department of Biochemistry and Molecular Biology and Proteomics Core Facility, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Xizeng Mao
2Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Xingzhi Song
2Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Jianhua Zhang
2Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Lan V. Pham
7Department of Hematopathology, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Philip L. Lorenzi
8Proteomics and Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Joseph Marszalek
4Institute for Applied Cancer Science and Center for Co-Clinical Trials, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Tim Heffernan
4Institute for Applied Cancer Science and Center for Co-Clinical Trials, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Giulio Draetta
2Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
4Institute for Applied Cancer Science and Center for Co-Clinical Trials, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Philip Jones
4Institute for Applied Cancer Science and Center for Co-Clinical Trials, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Andrew Futreal
2Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Krystle Nomie
1Department of Lymphoma and Myeloma, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Linghua Wang
2Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Michael Wang
1Department of Lymphoma and Myeloma, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
9Department of Stem Cell Transplantation and Cellular Therapy, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
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