Research ArticleBIOMATERIALS

Nanofiber-hydrogel composite–mediated angiogenesis for soft tissue reconstruction

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Science Translational Medicine  01 May 2019:
Vol. 11, Issue 490, eaau6210
DOI: 10.1126/scitranslmed.aau6210

Crafting a (re)constructive composite

To be useful for soft tissue reconstruction, a biomaterial should be compatible with surgical manipulation while providing material properties similar to the native tissue and should not promote scarring or adverse cell activation. Toward this goal, Li et al, developed an injectable, biodegradable composite biomaterial composed of hyaluronic acid hydrogel with embedded synthetic polymer fibers. Human cells formed vascular-like networks within the material in vitro, and subcutaneously implanted material showed macrophage infiltration and angiogenesis in rats. Macrophages were polarized toward a pro-regenerative phenotype, and the material facilitated adipose soft tissue defect repair in a rabbit model.

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