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Aβ and tau prion-like activities decline with longevity in the Alzheimer’s disease human brain

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Science Translational Medicine  01 May 2019:
Vol. 11, Issue 490, eaat8462
DOI: 10.1126/scitranslmed.aat8462

Article Information

vol. 11 no. 490

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication April 10, 2018
  • Accepted for publication January 11, 2019
  • .

Author Information

  1. Atsushi Aoyagi1,2,*,
  2. Carlo Condello1,3,*,,
  3. Jan Stöhr1,3,4,
  4. Weizhou Yue1,
  5. Brianna M. Rivera1,
  6. Joanne C. Lee1,
  7. Amanda L. Woerman1,3,
  8. Glenda Halliday5,
  9. Sjoerd van Duinen6,
  10. Martin Ingelsson7,
  11. Lars Lannfelt7,
  12. Caroline Graff8,9,
  13. Thomas D. Bird10,11,
  14. C. Dirk Keene12,
  15. William W. Seeley3,13,
  16. William F. DeGrado1,14 and
  17. Stanley B. Prusiner1,3,15,
  1. 1Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
  2. 2Daiichi Sankyo Co. Ltd., Tokyo 140-8710, Japan.
  3. 3Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
  4. 4AC Immune SA, EPFL Innovation Park, Building B, 1015 Lausanne, Switzerland.
  5. 5NeuRA and School of Medical Sciences, University of New South Wales, and Brain and Mind Centre, University of Sydney, Sydney, NSW 2052, Australia.
  6. 6Leiden University Medical Center, Leiden, Netherlands.
  7. 7Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, 751 85 Uppsala, Sweden.
  8. 8Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Solna, Sweden.
  9. 9Unit for Hereditary Dementias, Theme Aging, Karolinska University Hospital, Solna, Sweden.
  10. 10Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA.
  11. 11Department of Neurology, University of Washington, Seattle, WA 98195, USA.
  12. 12Department of Neuropathology, University of Washington School of Medicine, Seattle, WA 98195, USA.
  13. 13Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
  14. 14Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.
  15. 15Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
  1. Corresponding author. Email: carlo.condello{at}ucsf.edu (C.C.); stanley.prusiner{at}ucsf.edu (S.B.P.)
  • * These authors contributed equally to this work.

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