Research ArticleMultiple Sclerosis

Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects

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Science Translational Medicine  01 May 2019:
Vol. 11, Issue 490, eaao5563
DOI: 10.1126/scitranslmed.aao5563

Article Information

vol. 11 no. 490

PubMed: 
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History: 
  • Received for publication August 18, 2017
  • Resubmitted August 20, 2018
  • Accepted for publication April 2, 2019
  • .

Author Information

  1. Luisa Klotz1,*,,
  2. Melanie Eschborn1,*,
  3. Maren Lindner1,*,
  4. Marie Liebmann1,
  5. Martin Herold1,
  6. Claudia Janoschka1,
  7. Belén Torres Garrido1,
  8. Andreas Schulte-Mecklenbeck1,
  9. Catharina C. Gross1,
  10. Johanna Breuer1,
  11. Petra Hundehege1,
  12. Vilmos Posevitz1,
  13. Béatrice Pignolet2,
  14. Giulia Nebel3,
  15. Shirin Glander4,
  16. Nicole Freise5,
  17. Judith Austermann5,
  18. Timo Wirth1,
  19. Graham R. Campbell6,
  20. Tilman Schneider-Hohendorf1,
  21. Maria Eveslage7,
  22. David Brassat2,
  23. Nicholas Schwab1,
  24. Karin Loser8,
  25. Johannes Roth5,
  26. Karin B. Busch3,
  27. Monika Stoll4,9,
  28. Don J. Mahad6,
  29. Sven G. Meuth1,
  30. Timothy Turner10,
  31. Amit Bar-Or11 and
  32. Heinz Wiendl1,12
  1. 1University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
  2. 2CRC-SEP, Neurosciences Department, Toulouse University Hospital and INSERM U1043 - CNRS UMR 5282, Centre de Physiopathologie Toulouse-Purpan, Université Toulouse III, 31300 Toulouse, France.
  3. 3University of Münster, Institute of Molecular Cell Biology, 48149 Münster, Germany.
  4. 4University of Münster, Department of Genetic Epidemiology, 48149 Münster, Germany.
  5. 5University of Münster, Department of Immunology, 48149 Münster, Germany.
  6. 6University of Edinburgh, Centre for Clinical Brain Sciences, EH8 9YL Edinburgh, UK.
  7. 7University of Münster, Institute of Biostatistics and Clinical Research, 48149 Münster, Germany.
  8. 8University Hospital Münster, Department of Dermatology, 48149 Münster, Germany.
  9. 9Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, 6229 ER Maastricht, Netherlands.
  10. 10Sanofi Genzyme, Cambridge, MA 02142, USA.
  11. 11Center for Neuroinflammation and Experimental Therapeutics and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  12. 12Brain and Mind Centre, Medical Faculty, University of Sydney, Sydney, Camperdown, NSW 2050, Australia.
  1. Corresponding author. Email: luisa.klotz{at}ukmuenster.de
  • * These authors contributed equally to this work.

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