01 May 2019
Vol 11, Issue 490

About The Cover

Cover image expansion

ONLINE COVER Mighty Mitochondria. Pictured here is a mitochondrion, which can be functionally impaired by the multiple sclerosis (MS) immunomodulatory drug teriflunomide. To examine how teriflunomide affects cells in patients with MS, Klotz et al. studied blood samples from a clinical trial and performed mechanistic work in mouse models. They found that teriflunomide treatment distorted the T cell repertoire in patients with MS. Teriflunomide did not affect mitochondrial metabolism in all cells equivalently; rather, the drug preferentially interfered with high-affinity T cells to dampen autoimmune responses. [CREDIT: SPENCER SUTTON/SCIENCE SOURCE]