Contents
01 May 2019
Vol 11, Issue 490
Vol 11, Issue 490
Research Articles
- Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects
Inhibition of a mitochondrial enzyme during multiple sclerosis treatment modulates antigen-specific T cell responses in an affinity-dependent fashion.
- Nanofiber-hydrogel composite–mediated angiogenesis for soft tissue reconstruction
A biodegradable nanofiber-hydrogel composite material promotes angiogenesis for soft tissue reconstruction in rodent and rabbit models.
- Quorum sensing between bacterial species on the skin protects against epidermal injury in atopic dermatitis
Quorum sensing peptides produced by commensal skin staphylococci protect against skin injury and inflammation induced by Staphylococcus aureus toxins.
- Oxytocin antagonism prevents pregnancy-associated aortic dissection in a mouse model of Marfan syndrome
Protection from pregnancy-associated aortic dissection is achieved by decreasing oxytocin-induced ERK signaling in a mouse model of Marfan syndrome.
Research Resource
- Aβ and tau prion-like activities decline with longevity in the Alzheimer’s disease human brain
Cellular assays reveal a decline in Aβ and tau pathological conformers in Alzheimer’s disease brain samples.
Focus
- Exacting Edward Jenner’s revenge: The quest for a new tuberculosis vaccine
Recent experimental and clinical work has reinvigorated the pursuit of a better tuberculosis vaccine.
Editors' Choice
- Neurogenesis takes a hit in Alzheimer’s disease
New neurons are born in healthy humans throughout aging but decline in Alzheimer's disease, linking a loss of neurogenesis with disease progression.
- Fabricating a new heart: One step closer to reality
Cardiomyocytes and endothelial cells printed in omentum-derived hydrogels generate perfusable thick heart tissue that can be implanted in rodents.
- Somatic mutations are improving their bad rap
Recurrent somatic mutations could help protect the liver from injury.
Erratum
About The Cover
ONLINE COVER Mighty Mitochondria. Pictured here is a mitochondrion, which can be functionally impaired by the multiple sclerosis (MS) immunomodulatory drug teriflunomide. To examine how teriflunomide affects cells in patients with MS, Klotz et al. studied blood samples from a clinical trial and performed mechanistic work in mouse models. They found that teriflunomide treatment distorted the T cell repertoire in patients with MS. Teriflunomide did not affect mitochondrial metabolism in all cells equivalently; rather, the drug preferentially interfered with high-affinity T cells to dampen autoimmune responses. [CREDIT: SPENCER SUTTON/SCIENCE SOURCE]