Research ArticleMetabolism

The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans

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Science Translational Medicine  24 Apr 2019:
Vol. 11, Issue 489, eaav0120
DOI: 10.1126/scitranslmed.aav0120

Article Information

vol. 11 no. 489

PubMed: 
Print ISSN: 
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History: 
  • Received for publication August 6, 2018
  • Accepted for publication October 22, 2018
  • .

Author Information

  1. Amir Tirosh1,2,3,4,*,,
  2. Ediz S. Calay3,*,
  3. Gurol Tuncman3,*,
  4. Kathryn C. Claiborn3,
  5. Karen E. Inouye3,
  6. Kosei Eguchi3,
  7. Michael Alcala3,
  8. Moran Rathaus1,
  9. Kenneth S. Hollander1,2,
  10. Idit Ron1,
  11. Rinat Livne1,
  12. Yoriko Heianza5,
  13. Lu Qi5,
  14. Iris Shai6,
  15. Rajesh Garg4,7 and
  16. Gökhan S. Hotamisligil3,8,
  1. 1Dalia and David Arabov Endocrinology and Diabetes Research Center, Institute of Endocrinology, Sheba Medical Center, Tel-Hashomer, Israel.
  2. 2Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
  3. 3Department of Genetics and Complex Diseases & Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  4. 4Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA.
  5. 5Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
  6. 6Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
  7. 7Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine, 5555 Ponce de Leon Boulevard, Coral Gables, FL, USA.
  8. 8Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  1. Corresponding author. Email: ghotamis{at}hsph.harvard.edu (G.S.H.); amir.tirosh{at}sheba.health.gov.il (A.T.)
  • * These authors contributed equally to this work.

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