Research ArticleCardiology

Chronic hypoxia–induced Cirbp hypermethylation attenuates hypothermic cardioprotection via down-regulation of ubiquinone biosynthesis

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Science Translational Medicine  24 Apr 2019:
Vol. 11, Issue 489, eaat8406
DOI: 10.1126/scitranslmed.aat8406

Article Information

vol. 11 no. 489

PubMed: 
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History: 
  • Received for publication April 10, 2018
  • Resubmitted October 25, 2018
  • Accepted for publication March 25, 2019
  • .

Author Information

  1. Yiwei Liu1,*,
  2. Junyue Xing1,2,*,
  3. Yongnan Li1,3,
  4. Qipeng Luo1,
  5. Zhanhao Su1,
  6. Xiaoling Zhang1,2 and
  7. Hao Zhang1,2,4,5,
  1. 1State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
  2. 2Heart Center of Henan Provincial People Hospital and Key Laboratory of Cardiac Regenerative Medicine, National Health Commission, Zhengzhou 451464, China.
  3. 3Department of Cardiac Surgery, Lanzhou University Second Hospital, Lanzhou University, Lanzhou 730030, China.
  4. 4Center for Pediatric Cardiac Surgery, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
  5. 5Heart Center and Shanghai Institute of Pediatric Congenital Heart Diseases, Shanghai Children’s Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.
  1. Corresponding author. Email: drzhanghao{at}yahoo.com
  • * These authors contributed equally to this work.

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