Research ArticleAutoimmunity
A CD40L-targeting protein reduces autoantibodies and improves disease activity in patients with autoimmunity
- View ORCID ProfileJodi L. Karnell1,*,
- Marius Albulescu2,*,
- View ORCID ProfileStacey Drabic3,*,†,
- Liangwei Wang1,
- Rachel Moate4,
- Manuel Baca3,†,
- View ORCID ProfileVaheh Oganesyan3,
- View ORCID ProfileMichele Gunsior1,
- Thomas Thisted3,‡,
- Li Yan1,
- Jing Li5,
- Ximing Xiong3,
- View ORCID ProfileSteven C. Eck3,
- View ORCID ProfileMelissa de los Reyes3,
- Isharat Yusuf3,§,
- View ORCID ProfileKatie Streicher3,
- Ulf Müller-Ladner6,
- View ORCID ProfileDavid Howe4,||,
- Rachel Ettinger1,
- View ORCID ProfileRonald Herbst3,¶ and
- View ORCID ProfileJörn Drappa1,¶
- 1Viela Bio, Gaithersburg, MD 20878, USA.
- 2AstraZeneca, Cambridge CB4 OWG, UK.
- 3MedImmune, Gaithersburg, MD 20878, USA.
- 4MedImmune, Granta Park, Cambridge CB21 6GH, UK.
- 5MedImmune, San Francisco, CA 94080, USA.
- 6Department of Rheumatology and Clinical Immunology, Campus Kerchoff, Justus-Liebig University Giessen, 61231 Bad Nauheim, Germany.
- ↵¶Corresponding author. Email: herbstro{at}medimmune.com (R.H.); drappaj{at}vielabio.com (J.D.)
↵* These authors contributed equally to this work.
↵† Present address: Gilead Sciences Inc., Foster City, CA 94404, USA.
↵‡ Present address: Antidote Therapeutics Inc., Gaithersburg, MD 20878, USA.
↵§ Present address: Gossamer Bio, San Diego, CA 92121, USA.
↵|| Present address: Heptares Therapeutics Ltd., Cambridge CB21 6DG, UK.
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Science Translational Medicine 24 Apr 2019:
Vol. 11, Issue 489, eaar6584
DOI: 10.1126/scitranslmed.aar6584
Vol. 11, Issue 489, eaar6584
DOI: 10.1126/scitranslmed.aar6584
Jodi L. Karnell
1Viela Bio, Gaithersburg, MD 20878, USA.
Marius Albulescu
2AstraZeneca, Cambridge CB4 OWG, UK.
Stacey Drabic
3MedImmune, Gaithersburg, MD 20878, USA.
Liangwei Wang
1Viela Bio, Gaithersburg, MD 20878, USA.
Rachel Moate
4MedImmune, Granta Park, Cambridge CB21 6GH, UK.
Manuel Baca
3MedImmune, Gaithersburg, MD 20878, USA.
Vaheh Oganesyan
3MedImmune, Gaithersburg, MD 20878, USA.
Michele Gunsior
1Viela Bio, Gaithersburg, MD 20878, USA.
Thomas Thisted
3MedImmune, Gaithersburg, MD 20878, USA.
Li Yan
1Viela Bio, Gaithersburg, MD 20878, USA.
Jing Li
5MedImmune, San Francisco, CA 94080, USA.
Ximing Xiong
3MedImmune, Gaithersburg, MD 20878, USA.
Steven C. Eck
3MedImmune, Gaithersburg, MD 20878, USA.
Melissa de los Reyes
3MedImmune, Gaithersburg, MD 20878, USA.
Isharat Yusuf
3MedImmune, Gaithersburg, MD 20878, USA.
Katie Streicher
3MedImmune, Gaithersburg, MD 20878, USA.
Ulf Müller-Ladner
6Department of Rheumatology and Clinical Immunology, Campus Kerchoff, Justus-Liebig University Giessen, 61231 Bad Nauheim, Germany.
David Howe
4MedImmune, Granta Park, Cambridge CB21 6GH, UK.
Rachel Ettinger
1Viela Bio, Gaithersburg, MD 20878, USA.
Ronald Herbst
3MedImmune, Gaithersburg, MD 20878, USA.
Jörn Drappa
1Viela Bio, Gaithersburg, MD 20878, USA.
