Research ArticleAutoimmunity

A CD40L-targeting protein reduces autoantibodies and improves disease activity in patients with autoimmunity

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Science Translational Medicine  24 Apr 2019:
Vol. 11, Issue 489, eaar6584
DOI: 10.1126/scitranslmed.aar6584

Article Information

vol. 11 no. 489

PubMed: 
Print ISSN: 
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History: 
  • Received for publication December 4, 2017
  • Resubmitted November 6, 2018
  • Accepted for publication March 25, 2019
  • .

Author Information

  1. Jodi L. Karnell1,*,
  2. Marius Albulescu2,*,
  3. Stacey Drabic3,*,,
  4. Liangwei Wang1,
  5. Rachel Moate4,
  6. Manuel Baca3,,
  7. Vaheh Oganesyan3,
  8. Michele Gunsior1,
  9. Thomas Thisted3,,
  10. Li Yan1,
  11. Jing Li5,
  12. Ximing Xiong3,
  13. Steven C. Eck3,
  14. Melissa de los Reyes3,
  15. Isharat Yusuf3,§,
  16. Katie Streicher3,
  17. Ulf Müller-Ladner6,
  18. David Howe4,||,
  19. Rachel Ettinger1,
  20. Ronald Herbst3, and
  21. Jörn Drappa1,
  1. 1Viela Bio, Gaithersburg, MD 20878, USA.
  2. 2AstraZeneca, Cambridge CB4 OWG, UK.
  3. 3MedImmune, Gaithersburg, MD 20878, USA.
  4. 4MedImmune, Granta Park, Cambridge CB21 6GH, UK.
  5. 5MedImmune, San Francisco, CA 94080, USA.
  6. 6Department of Rheumatology and Clinical Immunology, Campus Kerchoff, Justus-Liebig University Giessen, 61231 Bad Nauheim, Germany.
  1. Corresponding author. Email: herbstro{at}medimmune.com (R.H.); drappaj{at}vielabio.com (J.D.)
  • * These authors contributed equally to this work.

  • Present address: Gilead Sciences Inc., Foster City, CA 94404, USA.

  • Present address: Antidote Therapeutics Inc., Gaithersburg, MD 20878, USA.

  • § Present address: Gossamer Bio, San Diego, CA 92121, USA.

  • || Present address: Heptares Therapeutics Ltd., Cambridge CB21 6DG, UK.

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