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Research ArticleBONE HEALING
A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix
- View ORCID ProfileHoward J. Seeherman1,*,
- Stephen P. Berasi2,
- Christopher T. Brown1,
- View ORCID ProfileRobert X. Martinez3,
- View ORCID ProfileZ. Sean Juo4,
- View ORCID ProfileScott Jelinsky3,
- Michael J. Cain3,
- View ORCID ProfileJaclyn Grode1,
- Kathleen E. Tumelty2,
- View ORCID ProfileMarc Bohner5,
- Orly Grinberg6,
- Nadav Orr6,
- Oded Shoseyov6,
- View ORCID ProfileJeroen Eyckmans7,8,
- View ORCID ProfileChristopher Chen7,8,
- Pablo R. Morales9,
- View ORCID ProfileChristopher G. Wilson1,
- View ORCID ProfileEric J. Vanderploeg1 and
- John M. Wozney1
- 1Bioventus Surgical, Bioventus LLC, Boston, MA 02215, USA.
- 2Centers for Therapeutic Innovation, Pfizer Inc., Boston, MA 02115, USA.
- 3Department of Inflammation and Immunology, Pfizer Inc., Cambridge, MA 02139, USA.
- 4Biomedical Design, Pfizer Inc., Cambridge, MA 02139, USA.
- 5Robert Mathys Stiftung (RMS) Foundation, Bettlach 2544, Switzerland.
- 6CollPlant Ltd., Ness Ziona 74140, Israel.
- 7Biological Design Center and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
- 8Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA.
- 9Mannheimer Foundation Inc., Homestead, FL 33034, USA.
- ↵*Corresponding author. Email: hseeherman{at}gmail.com
See allHide authors and affiliations
Science Translational Medicine 24 Apr 2019:
Vol. 11, Issue 489, eaar4953
DOI: 10.1126/scitranslmed.aar4953
Vol. 11, Issue 489, eaar4953
DOI: 10.1126/scitranslmed.aar4953
Howard J. Seeherman
1Bioventus Surgical, Bioventus LLC, Boston, MA 02215, USA.
Stephen P. Berasi
2Centers for Therapeutic Innovation, Pfizer Inc., Boston, MA 02115, USA.
Christopher T. Brown
1Bioventus Surgical, Bioventus LLC, Boston, MA 02215, USA.
Robert X. Martinez
3Department of Inflammation and Immunology, Pfizer Inc., Cambridge, MA 02139, USA.
Z. Sean Juo
4Biomedical Design, Pfizer Inc., Cambridge, MA 02139, USA.
Scott Jelinsky
3Department of Inflammation and Immunology, Pfizer Inc., Cambridge, MA 02139, USA.
Michael J. Cain
3Department of Inflammation and Immunology, Pfizer Inc., Cambridge, MA 02139, USA.
Jaclyn Grode
1Bioventus Surgical, Bioventus LLC, Boston, MA 02215, USA.
Kathleen E. Tumelty
2Centers for Therapeutic Innovation, Pfizer Inc., Boston, MA 02115, USA.
Marc Bohner
5Robert Mathys Stiftung (RMS) Foundation, Bettlach 2544, Switzerland.
Orly Grinberg
6CollPlant Ltd., Ness Ziona 74140, Israel.
Nadav Orr
6CollPlant Ltd., Ness Ziona 74140, Israel.
Oded Shoseyov
6CollPlant Ltd., Ness Ziona 74140, Israel.
Jeroen Eyckmans
7Biological Design Center and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
8Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA.
Christopher Chen
7Biological Design Center and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
8Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA.
Pablo R. Morales
9Mannheimer Foundation Inc., Homestead, FL 33034, USA.
Christopher G. Wilson
1Bioventus Surgical, Bioventus LLC, Boston, MA 02215, USA.
Eric J. Vanderploeg
1Bioventus Surgical, Bioventus LLC, Boston, MA 02215, USA.
John M. Wozney
1Bioventus Surgical, Bioventus LLC, Boston, MA 02215, USA.
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