Research ArticleBONE HEALING

A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix

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Science Translational Medicine  24 Apr 2019:
Vol. 11, Issue 489, eaar4953
DOI: 10.1126/scitranslmed.aar4953

Article Information

vol. 11 no. 489

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History: 
  • Received for publication November 17, 2017
  • Resubmitted July 19, 2018
  • Accepted for publication March 11, 2019
  • .

Author Information

  1. Howard J. Seeherman1,*,
  2. Stephen P. Berasi2,
  3. Christopher T. Brown1,
  4. Robert X. Martinez3,
  5. Z. Sean Juo4,
  6. Scott Jelinsky3,
  7. Michael J. Cain3,
  8. Jaclyn Grode1,
  9. Kathleen E. Tumelty2,
  10. Marc Bohner5,
  11. Orly Grinberg6,
  12. Nadav Orr6,
  13. Oded Shoseyov6,
  14. Jeroen Eyckmans7,8,
  15. Christopher Chen7,8,
  16. Pablo R. Morales9,
  17. Christopher G. Wilson1,
  18. Eric J. Vanderploeg1 and
  19. John M. Wozney1
  1. 1Bioventus Surgical, Bioventus LLC, Boston, MA 02215, USA.
  2. 2Centers for Therapeutic Innovation, Pfizer Inc., Boston, MA 02115, USA.
  3. 3Department of Inflammation and Immunology, Pfizer Inc., Cambridge, MA 02139, USA.
  4. 4Biomedical Design, Pfizer Inc., Cambridge, MA 02139, USA.
  5. 5Robert Mathys Stiftung (RMS) Foundation, Bettlach 2544, Switzerland.
  6. 6CollPlant Ltd., Ness Ziona 74140, Israel.
  7. 7Biological Design Center and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
  8. 8Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA.
  9. 9Mannheimer Foundation Inc., Homestead, FL 33034, USA.
  1. *Corresponding author. Email: hseeherman{at}gmail.com

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