Filamentous bacteriophages are associated with chronic Pseudomonas lung infections and antibiotic resistance in cystic fibrosis

Elizabeth B. Burgener; Johanna M. Sweere; Michelle S. Bach; Patrick R. Secor; Naomi Haddock; Laura K. Jennings; Rasmus L. Marvig; Helle Krogh Johansen; Elio Rossi; Xiou Cao; Lu Tian; Laurence Nedelec; Søren Molin; Paul L. Bollyky; Carlos E. Milla

doi:10.1126/scitranslmed.aau9748

Research ArticleCystic Fibrosis

Filamentous bacteriophages are associated with chronic Pseudomonas lung infections and antibiotic resistance in cystic fibrosis

View ORCID ProfileElizabeth B. Burgener ¹,*,
View ORCID ProfileJohanna M. Sweere²,³,
View ORCID ProfileMichelle S. Bach²,
View ORCID ProfilePatrick R. Secor⁴,
View ORCID ProfileNaomi Haddock³,
View ORCID ProfileLaura K. Jennings⁴,
View ORCID ProfileRasmus L. Marvig⁵,
View ORCID ProfileHelle Krogh Johansen⁶,⁷,
View ORCID ProfileElio Rossi⁶,
View ORCID ProfileXiou Cao²,
Lu Tian⁸,
Laurence Nedelec⁹,
View ORCID ProfileSøren Molin¹⁰,
View ORCID ProfilePaul L. Bollyky ²,³,† and
Carlos E. Milla¹,†

¹Center for Excellence in Pulmonary Biology, Department of Pediatrics, Stanford University, Stanford, CA 94305, USA.
²Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA.
³Stanford Immunology, Stanford University, Stanford, CA 94305, USA.
⁴Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA.
⁵Center for Genomic Medicine, Rigshospitalet–Copenhagen University Hospital, Copenhagen, Denmark.
⁶Department of Clinical Microbiology, Rigshospitalet, Copenhagen Ø, Denmark.
⁷Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark.
⁸Biomedical Data Science Administration and Statistics, Stanford University, Stanford, CA 94305, USA.
⁹Primary Care and Population Health, Stanford University, Stanford, CA 94305, USA.
¹⁰The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark.

↵*Corresponding author. Email: eburgener{at}stanford.edu

↵† Co-senior authors.

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Science Translational Medicine 17 Apr 2019:
Vol. 11, Issue 488, eaau9748
DOI: 10.1126/scitranslmed.aau9748

Elizabeth B. Burgener

1Center for Excellence in Pulmonary Biology, Department of Pediatrics, Stanford University, Stanford, CA 94305, USA.

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For correspondence: eburgener@stanford.edu

Johanna M. Sweere

2Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA.

3Stanford Immunology, Stanford University, Stanford, CA 94305, USA.

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Michelle S. Bach

2Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA.

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Patrick R. Secor

4Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA.

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Naomi Haddock

3Stanford Immunology, Stanford University, Stanford, CA 94305, USA.

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Laura K. Jennings

4Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA.

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Rasmus L. Marvig

5Center for Genomic Medicine, Rigshospitalet–Copenhagen University Hospital, Copenhagen, Denmark.

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Helle Krogh Johansen

6Department of Clinical Microbiology, Rigshospitalet, Copenhagen Ø, Denmark.

7Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark.

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Elio Rossi

6Department of Clinical Microbiology, Rigshospitalet, Copenhagen Ø, Denmark.

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Xiou Cao

2Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA.

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Lu Tian

8Biomedical Data Science Administration and Statistics, Stanford University, Stanford, CA 94305, USA.

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Laurence Nedelec

9Primary Care and Population Health, Stanford University, Stanford, CA 94305, USA.

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Søren Molin

9Primary Care and Population Health, Stanford University, Stanford, CA 94305, USA.

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Paul L. Bollyky

2Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA.

3Stanford Immunology, Stanford University, Stanford, CA 94305, USA.

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Carlos E. Milla

1Center for Excellence in Pulmonary Biology, Department of Pediatrics, Stanford University, Stanford, CA 94305, USA.

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Pseudomonas strains that produce filamentous bacteriophage are associated with chronic infection and increased antibiotic resistance in patients with cystic fibrosis.

Filamentous bacteriophages are associated with chronic Pseudomonas lung infections and antibiotic resistance in cystic fibrosis

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