Research ArticleMetabolism

Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1

See allHide authors and affiliations

Science Translational Medicine  17 Apr 2019:
Vol. 11, Issue 488, eaau7116
DOI: 10.1126/scitranslmed.aau7116

Article Information

vol. 11 no. 488

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication October 4, 2018
  • Accepted for publication March 25, 2019
  • .

Author Information

  1. Shiming Peng1,*,
  2. Wen Xiao2,*,
  3. Dapeng Ju1,*,
  4. Baofa Sun2,3,4,*,
  5. Nannan Hou1,
  6. Qianlan Liu2,3,
  7. Yanli Wang1,
  8. Haijiao Zhao1,
  9. Chunchun Gao2,3,
  10. Song Zhang5,
  11. Ran Cao1,
  12. Pengfei Li1,
  13. Huanwei Huang1,
  14. Yongfen Ma1,
  15. Yankai Wang1,
  16. Weiyi Lai6,
  17. Zhixiong Ma1,
  18. Wei Zhang1,
  19. Song Huang1,
  20. Hailin Wang6,
  21. Zhiyuan Zhang1,
  22. Liping Zhao1,
  23. Tao Cai1,
  24. Yong-Liang Zhao2,3,
  25. Fengchao Wang1,
  26. Yongzhan Nie5,
  27. Gang Zhi1,
  28. Yun-Gui Yang2,3,4,,
  29. Eric Erquan Zhang1,7, and
  30. Niu Huang1,7,
  1. 1National Institute of Biological Sciences, Beijing, No. 7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, China.
  2. 2Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, No. 1 Beichen West Road, Chaoyang District, Beijing 100101, China.
  3. 3University of Chinese Academy of Sciences, Beijing 100049, China.
  4. 4Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.
  5. 5State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West Changle Road, Xi’an, Shaanxi 710032, China.
  6. 6State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
  7. 7Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 102206, China.
  1. Corresponding author. Email: ygyang{at}big.ac.cn (Y.-G.Y.); zhangerquan{at}nibs.ac.cn (E.E.Z.); huangniu{at}nibs.ac.cn (N. Huang)
  • * These authors contributed equally to this work.

Altmetric

Article usage

Article usage: April 2019 to December 2019

AbstractFullPdf
Apr 201964991510616
May 2019539236198
Jun 2019419186128
Jul 2019307156110
Aug 201924014080
Sep 201918613163
Oct 201923112880
Nov 20192248067
Dec 2019944431

Stay Connected to
   Science Translational Medicine