17 April 2019
Vol 11, Issue 488

About The Cover

Cover image expansion

ONLINE COVER Gene Editing to the Rescue. This conceptual image depicts a mouse fetus having its DNA sequence corrected to repair a pathogenic mutation. Alapati et al.. used CRISPR-Cas9, a method of targeted gene editing, to inactivate a mutant version of Sftpc, a gene that causes a lethal congenital lung disease, in mice. Because the lung disease is lethal at the time of birth, the researchers performed gene editing in utero. Editing improved the survival of mouse pups without causing adverse effects in their mothers. [CREDIT: EO TRUEBLOOD/THE CHILDREN'S HOSPITAL OF PHILADELPHIA]