10 April 2019
Vol 11, Issue 487

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ONLINE COVER Activating Axonal Regeneration. Increasing neuronal activity by electrical stimulation or rehabilitation promotes axonal regeneration and recovery after spinal cord injury (SCI). The mechanisms mediating these effects were investigated in a rat model of SCI (Hutson et al.). This image shows a cultured sensory neuron with extensive axonal branches after incubation with a selective Creb-binding protein (Cbp) activator. Exposing rats with SCI to an enriched environment triggered axonal regeneration in sensory neurons by promoting Cbp-mediated histone acetylation. Pharmacological treatment with a Cbp activator mimicked the effect of environmental enrichment and boosted recovery after SCI in rats. [CREDIT: HUTSON ET AL./SCIENCE TRANSLATIONAL MEDICINE]