Research ArticleCystic Fibrosis

Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis

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Science Translational Medicine  03 Apr 2019:
Vol. 11, Issue 486, eaav3488
DOI: 10.1126/scitranslmed.aav3488

Article Information

vol. 11 no. 486

PubMed: 
Print ISSN: 
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History: 
  • Received for publication September 12, 2018
  • Accepted for publication March 10, 2019
  • .

Author Information

  1. Charles R. Esther Jr.1,2,*,,
  2. Marianne S. Muhlebach1,2,,
  3. Camille Ehre1,2,
  4. David B. Hill2,3,
  5. Matthew C. Wolfgang2,
  6. Mehmet Kesimer2,
  7. Kathryn A. Ramsey2,4,
  8. Matthew R. Markovetz2,
  9. Ian C. Garbarine2,
  10. M. Gregory Forest5,
  11. Ian Seim5,
  12. Bryan Zorn2,
  13. Cameron B. Morrison2,
  14. Martial F. Delion2,
  15. William R. Thelin6,
  16. Diane Villalon6,
  17. Juan R. Sabater7,
  18. Lidija Turkovic4,
  19. Sarath Ranganathan8,
  20. Stephen M. Stick4,9,10, and
  21. Richard C. Boucher2,
  1. 1Division of Pediatric Pulmonology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  2. 2Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  3. 3Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  4. 4Telethon Kids Institute, University of Western Australia, Perth 6009, Australia.
  5. 5Departments of Mathematics, Biomedical Engineering, and Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  6. 6Parion Sciences, Durham, NC 27713, USA.
  7. 7Department of Research, Mount Sinai Medical Center, Miami Beach, FL 33140, USA.
  8. 8Murdoch Children’s Research Institute, University of Melbourne, Parkville 3052, Australia.
  9. 9Division of Paediatrics and Child Health, University of Western Australia, Perth 6009, Australia.
  10. 10Princess Margaret Hospital for Children, Perth 6009, Australia.
  1. *Corresponding author. Email: charles_esther{at}med.unc.edu
  • These authors contributed equally to this work.

  • These authors contributed equally to this work as senior authors.

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