Research ArticleHIV
Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation
- View ORCID ProfileClaire D. Bourke1,*,†,
- View ORCID ProfileEthan K. Gough2,†,‡,
- Godfrey Pimundu3,
- View ORCID ProfileAnnie Shonhai4,
- Chipo Berejena4,
- Louise Terry5,
- View ORCID ProfileLucas Baumard1,
- View ORCID ProfileNaheed Choudhry1,
- Yusuf Karmali1,
- View ORCID ProfileMutsa Bwakura-Dangarembizi4,
- View ORCID ProfileVictor Musiime3,6,
- Joseph Lutaakome7,
- Adeodata Kekitiinwa8,
- Kuda Mutasa9,
- View ORCID ProfileAlexander J. Szubert10,
- View ORCID ProfileMoira J. Spyer10,
- Jane R. Deayton1,5,
- Magdalena Glass2,§,
- Hyun Min Geum2,
- View ORCID ProfileClaire Pardieu1,
- View ORCID ProfileDiana M. Gibb10,
- View ORCID ProfileNigel Klein11,
- Thaddeus J. Edens12,
- A. Sarah Walker10,
- View ORCID ProfileAmee R. Manges2,|| and
- Andrew J. Prendergast1,9,10,||
- 1Blizard Institute, Queen Mary University of London, London E1 2AT, UK.
- 2School of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
- 3Joint Clinical Research Centre, Kampala, Uganda.
- 4College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
- 5Royal London Hospital, Barts Health NHS Trust, London E1 1BB, UK.
- 6College of Health Sciences, Department of Paediatrics and Child Health, Makerere University, Kampala, Uganda.
- 7Uganda Virus Research Institute/MRC Uganda Research Unit on AIDS, Entebbe, Uganda.
- 8Baylor College of Medicine Children’s Foundation—Uganda, Mulago Hospital, Kampala, Uganda.
- 9Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
- 10MRC Clinical Trials Unit at University College London, London WC1V 6LJ, UK.
- 11UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.
- 12Devil’s Staircase Consulting, West Vancouver, British Columbia V7T 1V7, Canada.
- ↵*Corresponding author. Email: c.bourke{at}qmul.ac.uk
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Science Translational Medicine 03 Apr 2019:
Vol. 11, Issue 486, eaav0537
DOI: 10.1126/scitranslmed.aav0537
Vol. 11, Issue 486, eaav0537
DOI: 10.1126/scitranslmed.aav0537
Claire D. Bourke
1Blizard Institute, Queen Mary University of London, London E1 2AT, UK.
Ethan K. Gough
2School of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Godfrey Pimundu
3Joint Clinical Research Centre, Kampala, Uganda.
Annie Shonhai
4College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
Chipo Berejena
4College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
Louise Terry
5Royal London Hospital, Barts Health NHS Trust, London E1 1BB, UK.
Lucas Baumard
1Blizard Institute, Queen Mary University of London, London E1 2AT, UK.
Naheed Choudhry
1Blizard Institute, Queen Mary University of London, London E1 2AT, UK.
Yusuf Karmali
1Blizard Institute, Queen Mary University of London, London E1 2AT, UK.
Mutsa Bwakura-Dangarembizi
4College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
Victor Musiime
3Joint Clinical Research Centre, Kampala, Uganda.
6College of Health Sciences, Department of Paediatrics and Child Health, Makerere University, Kampala, Uganda.
Joseph Lutaakome
7Uganda Virus Research Institute/MRC Uganda Research Unit on AIDS, Entebbe, Uganda.
Adeodata Kekitiinwa
8Baylor College of Medicine Children’s Foundation—Uganda, Mulago Hospital, Kampala, Uganda.
Kuda Mutasa
9Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Alexander J. Szubert
10MRC Clinical Trials Unit at University College London, London WC1V 6LJ, UK.
Moira J. Spyer
10MRC Clinical Trials Unit at University College London, London WC1V 6LJ, UK.
Jane R. Deayton
1Blizard Institute, Queen Mary University of London, London E1 2AT, UK.
5Royal London Hospital, Barts Health NHS Trust, London E1 1BB, UK.
Magdalena Glass
2School of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Hyun Min Geum
2School of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Claire Pardieu
1Blizard Institute, Queen Mary University of London, London E1 2AT, UK.
Diana M. Gibb
10MRC Clinical Trials Unit at University College London, London WC1V 6LJ, UK.
Nigel Klein
11UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.
Thaddeus J. Edens
12Devil’s Staircase Consulting, West Vancouver, British Columbia V7T 1V7, Canada.
A. Sarah Walker
10MRC Clinical Trials Unit at University College London, London WC1V 6LJ, UK.
Amee R. Manges
2School of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Andrew J. Prendergast
1Blizard Institute, Queen Mary University of London, London E1 2AT, UK.
9Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
10MRC Clinical Trials Unit at University College London, London WC1V 6LJ, UK.
