Research ArticleHIV
Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation
- Claire D. Bourke1,*,†,
- Ethan K. Gough2,†,‡,
- Godfrey Pimundu3,
- Annie Shonhai4,
- Chipo Berejena4,
- Louise Terry5,
- Lucas Baumard1,
- Naheed Choudhry1,
- Yusuf Karmali1,
- Mutsa Bwakura-Dangarembizi4,
- Victor Musiime3,6,
- Joseph Lutaakome7,
- Adeodata Kekitiinwa8,
- Kuda Mutasa9,
- Alexander J. Szubert10,
- Moira J. Spyer10,
- Jane R. Deayton1,5,
- Magdalena Glass2,§,
- Hyun Min Geum2,
- Claire Pardieu1,
- Diana M. Gibb10,
- Nigel Klein11,
- Thaddeus J. Edens12,
- A. Sarah Walker10,
- Amee R. Manges2,|| and
- Andrew J. Prendergast1,9,10,||
- 1Blizard Institute, Queen Mary University of London, London E1 2AT, UK.
- 2School of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
- 3Joint Clinical Research Centre, Kampala, Uganda.
- 4College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
- 5Royal London Hospital, Barts Health NHS Trust, London E1 1BB, UK.
- 6College of Health Sciences, Department of Paediatrics and Child Health, Makerere University, Kampala, Uganda.
- 7Uganda Virus Research Institute/MRC Uganda Research Unit on AIDS, Entebbe, Uganda.
- 8Baylor College of Medicine Children’s Foundation—Uganda, Mulago Hospital, Kampala, Uganda.
- 9Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
- 10MRC Clinical Trials Unit at University College London, London WC1V 6LJ, UK.
- 11UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.
- 12Devil’s Staircase Consulting, West Vancouver, British Columbia V7T 1V7, Canada.
- ↵*Corresponding author. Email: c.bourke{at}qmul.ac.uk
↵† These authors contributed equally to this work.
↵‡ Present address: Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
↵§ Present address: Canada’s Michael Smith Genome Sciences Centre, Vancouver, BC V5Z 4S6, Canada.
↵|| These authors contributed equally to this work.
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Science Translational Medicine 03 Apr 2019:
Vol. 11, Issue 486, eaav0537
DOI: 10.1126/scitranslmed.aav0537
