Research ArticleHIV

Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation

See allHide authors and affiliations

Science Translational Medicine  03 Apr 2019:
Vol. 11, Issue 486, eaav0537
DOI: 10.1126/scitranslmed.aav0537

Article Information

vol. 11 no. 486

Print ISSN: 
Online ISSN: 
  • Received for publication August 9, 2018
  • Resubmitted November 21, 2018
  • Accepted for publication February 14, 2019
  • .

Author Information

  1. Claire D. Bourke1,*,,
  2. Ethan K. Gough2,,,
  3. Godfrey Pimundu3,
  4. Annie Shonhai4,
  5. Chipo Berejena4,
  6. Louise Terry5,
  7. Lucas Baumard1,
  8. Naheed Choudhry1,
  9. Yusuf Karmali1,
  10. Mutsa Bwakura-Dangarembizi4,
  11. Victor Musiime3,6,
  12. Joseph Lutaakome7,
  13. Adeodata Kekitiinwa8,
  14. Kuda Mutasa9,
  15. Alexander J. Szubert10,
  16. Moira J. Spyer10,
  17. Jane R. Deayton1,5,
  18. Magdalena Glass2,§,
  19. Hyun Min Geum2,
  20. Claire Pardieu1,
  21. Diana M. Gibb10,
  22. Nigel Klein11,
  23. Thaddeus J. Edens12,
  24. A. Sarah Walker10,
  25. Amee R. Manges2,|| and
  26. Andrew J. Prendergast1,9,10,||
  1. 1Blizard Institute, Queen Mary University of London, London E1 2AT, UK.
  2. 2School of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
  3. 3Joint Clinical Research Centre, Kampala, Uganda.
  4. 4College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
  5. 5Royal London Hospital, Barts Health NHS Trust, London E1 1BB, UK.
  6. 6College of Health Sciences, Department of Paediatrics and Child Health, Makerere University, Kampala, Uganda.
  7. 7Uganda Virus Research Institute/MRC Uganda Research Unit on AIDS, Entebbe, Uganda.
  8. 8Baylor College of Medicine Children’s Foundation—Uganda, Mulago Hospital, Kampala, Uganda.
  9. 9Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
  10. 10MRC Clinical Trials Unit at University College London, London WC1V 6LJ, UK.
  11. 11UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.
  12. 12Devil’s Staircase Consulting, West Vancouver, British Columbia V7T 1V7, Canada.
  1. *Corresponding author. Email: c.bourke{at}
  • These authors contributed equally to this work.

  • Present address: Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

  • § Present address: Canada’s Michael Smith Genome Sciences Centre, Vancouver, BC V5Z 4S6, Canada.

  • || These authors contributed equally to this work.


Article usage

Article usage: April 2019 to July 2020

Apr 201962322640444
May 20199828743
Jun 20193346530
Jul 20191975325
Aug 20191153719
Sep 20191275127
Oct 20191784733
Nov 20191254023
Dec 20191062315
Jan 2020694714
Feb 2020703915
Mar 20201012011
Apr 20201810569
May 20203103104
Jun 20205106114
Jul 202023324

Stay Connected to Science Translational Medicine

Navigate This Article