Elastin imaging enables noninvasive staging and treatment monitoring of kidney fibrosis

Qinxue Sun; Maike Baues; Barbara M. Klinkhammer; Josef Ehling; Sonja Djudjaj; Natascha I. Drude; Christoph Daniel; Kerstin Amann; Rafael Kramann; Hyojin Kim; Julio Saez-Rodriguez; Ralf Weiskirchen; David C. Onthank; Rene M. Botnar; Fabian Kiessling; Jürgen Floege; Twan Lammers; Peter Boor

doi:10.1126/scitranslmed.aat4865

Research ArticleKidney Fibrosis

Elastin imaging enables noninvasive staging and treatment monitoring of kidney fibrosis

View ORCID ProfileQinxue Sun¹,²,*,
View ORCID ProfileMaike Baues³,*,
View ORCID ProfileBarbara M. Klinkhammer¹,⁴,*,
Josef Ehling³,
View ORCID ProfileSonja Djudjaj¹,
Natascha I. Drude³,⁵,
View ORCID ProfileChristoph Daniel⁶,
Kerstin Amann⁶,
Rafael Kramann⁴,
View ORCID ProfileHyojin Kim⁷,⁸,
View ORCID ProfileJulio Saez-Rodriguez⁷,⁸,
View ORCID ProfileRalf Weiskirchen⁹,
View ORCID ProfileDavid C. Onthank¹⁰,
Rene M. Botnar¹¹,
View ORCID ProfileFabian Kiessling³,
Jürgen Floege⁴,
View ORCID ProfileTwan Lammers³,¹²,† and
View ORCID ProfilePeter Boor¹,⁴,¹³,¹⁴,†

¹Institute of Pathology, RWTH Aachen University Hospital, 52074 Aachen, Germany.
²Department of Radiology, Ningbo Medical Center Li Huili Hospital, 315040 Ningbo, China.
³Institute for Experimental Molecular Imaging, RWTH Aachen University Hospital, 52074 Aachen, Germany.
⁴Department of Nephrology and Immunology, RWTH Aachen University Hospital, 52074 Aachen, Germany.
⁵Department for Nuclear Medicine, RWTH Aachen University Hospital, 52074 Aachen, Germany.
⁶Institute of Pathology and Department of Nephropathology, University Erlangen, 91054 Erlangen, Germany.
⁷Joint Research Center for Computational Biomedicine, RWTH Aachen University Hospital, 52074 Aachen, Germany.
⁸Institute of Computational Biomedicine, Heidelberg University, 69120 Heidelberg, Germany.
⁹Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH Aachen University Hospital, 52074 Aachen, Germany.
¹⁰Lantheus Medical Imaging, North Billerica, MA 01862, USA.
¹¹School of Biomedical Engineering and Imaging Sciences, King's College London, WC2R 2LS London, UK.
¹²Department of Targeted Therapeutics, University of Twente, 7522 NB Enschede, Netherlands.
¹³Electron Microscopy Facility, RWTH Aachen University Hospital, 52074 Aachen, Germany.
¹⁴Institute of Molecular Biomedicine, Comenius University, 81972 Bratislava, Slovakia.

↵†Corresponding author. Email: pboor{at}ukaachen.de (P.B.); tlammers{at}ukaachen.de (T.L.)

↵* These authors equally contributed to this work.

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Science Translational Medicine 03 Apr 2019:
Vol. 11, Issue 486, eaat4865
DOI: 10.1126/scitranslmed.aat4865

Qinxue Sun

1Institute of Pathology, RWTH Aachen University Hospital, 52074 Aachen, Germany.

2Department of Radiology, Ningbo Medical Center Li Huili Hospital, 315040 Ningbo, China.

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Maike Baues

3Institute for Experimental Molecular Imaging, RWTH Aachen University Hospital, 52074 Aachen, Germany.

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Barbara M. Klinkhammer

1Institute of Pathology, RWTH Aachen University Hospital, 52074 Aachen, Germany.

4Department of Nephrology and Immunology, RWTH Aachen University Hospital, 52074 Aachen, Germany.

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Josef Ehling

3Institute for Experimental Molecular Imaging, RWTH Aachen University Hospital, 52074 Aachen, Germany.

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Sonja Djudjaj

1Institute of Pathology, RWTH Aachen University Hospital, 52074 Aachen, Germany.

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Natascha I. Drude

3Institute for Experimental Molecular Imaging, RWTH Aachen University Hospital, 52074 Aachen, Germany.

5Department for Nuclear Medicine, RWTH Aachen University Hospital, 52074 Aachen, Germany.

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Christoph Daniel

6Institute of Pathology and Department of Nephropathology, University Erlangen, 91054 Erlangen, Germany.

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Kerstin Amann

6Institute of Pathology and Department of Nephropathology, University Erlangen, 91054 Erlangen, Germany.

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Rafael Kramann

4Department of Nephrology and Immunology, RWTH Aachen University Hospital, 52074 Aachen, Germany.

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Hyojin Kim

7Joint Research Center for Computational Biomedicine, RWTH Aachen University Hospital, 52074 Aachen, Germany.

8Institute of Computational Biomedicine, Heidelberg University, 69120 Heidelberg, Germany.

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Julio Saez-Rodriguez

7Joint Research Center for Computational Biomedicine, RWTH Aachen University Hospital, 52074 Aachen, Germany.

8Institute of Computational Biomedicine, Heidelberg University, 69120 Heidelberg, Germany.

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Ralf Weiskirchen

9Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH Aachen University Hospital, 52074 Aachen, Germany.

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David C. Onthank

10Lantheus Medical Imaging, North Billerica, MA 01862, USA.

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Rene M. Botnar

11School of Biomedical Engineering and Imaging Sciences, King's College London, WC2R 2LS London, UK.

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Fabian Kiessling

3Institute for Experimental Molecular Imaging, RWTH Aachen University Hospital, 52074 Aachen, Germany.

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Jürgen Floege

4Department of Nephrology and Immunology, RWTH Aachen University Hospital, 52074 Aachen, Germany.

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Twan Lammers

3Institute for Experimental Molecular Imaging, RWTH Aachen University Hospital, 52074 Aachen, Germany.

12Department of Targeted Therapeutics, University of Twente, 7522 NB Enschede, Netherlands.

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For correspondence: pboor@ukaachen.de tlammers@ukaachen.de

Peter Boor

1Institute of Pathology, RWTH Aachen University Hospital, 52074 Aachen, Germany.

4Department of Nephrology and Immunology, RWTH Aachen University Hospital, 52074 Aachen, Germany.

13Electron Microscopy Facility, RWTH Aachen University Hospital, 52074 Aachen, Germany.

14Institute of Molecular Biomedicine, Comenius University, 81972 Bratislava, Slovakia.

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For correspondence: pboor@ukaachen.de tlammers@ukaachen.de

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Elastin imaging enables noninvasive staging and treatment monitoring of kidney fibrosis

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