Research ArticleKidney Fibrosis

Elastin imaging enables noninvasive staging and treatment monitoring of kidney fibrosis

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Science Translational Medicine  03 Apr 2019:
Vol. 11, Issue 486, eaat4865
DOI: 10.1126/scitranslmed.aat4865

Article Information

vol. 11 no. 486

PubMed: 
Print ISSN: 
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History: 
  • Received for publication March 3, 2018
  • Resubmitted November 28, 2018
  • Accepted for publication March 11, 2019
  • .

Author Information

  1. Qinxue Sun1,2,*,
  2. Maike Baues3,*,
  3. Barbara M. Klinkhammer1,4,*,
  4. Josef Ehling3,
  5. Sonja Djudjaj1,
  6. Natascha I. Drude3,5,
  7. Christoph Daniel6,
  8. Kerstin Amann6,
  9. Rafael Kramann4,
  10. Hyojin Kim7,8,
  11. Julio Saez-Rodriguez7,8,
  12. Ralf Weiskirchen9,
  13. David C. Onthank10,
  14. Rene M. Botnar11,
  15. Fabian Kiessling3,
  16. Jürgen Floege4,
  17. Twan Lammers3,12, and
  18. Peter Boor1,4,13,14,
  1. 1Institute of Pathology, RWTH Aachen University Hospital, 52074 Aachen, Germany.
  2. 2Department of Radiology, Ningbo Medical Center Li Huili Hospital, 315040 Ningbo, China.
  3. 3Institute for Experimental Molecular Imaging, RWTH Aachen University Hospital, 52074 Aachen, Germany.
  4. 4Department of Nephrology and Immunology, RWTH Aachen University Hospital, 52074 Aachen, Germany.
  5. 5Department for Nuclear Medicine, RWTH Aachen University Hospital, 52074 Aachen, Germany.
  6. 6Institute of Pathology and Department of Nephropathology, University Erlangen, 91054 Erlangen, Germany.
  7. 7Joint Research Center for Computational Biomedicine, RWTH Aachen University Hospital, 52074 Aachen, Germany.
  8. 8Institute of Computational Biomedicine, Heidelberg University, 69120 Heidelberg, Germany.
  9. 9Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH Aachen University Hospital, 52074 Aachen, Germany.
  10. 10Lantheus Medical Imaging, North Billerica, MA 01862, USA.
  11. 11School of Biomedical Engineering and Imaging Sciences, King's College London, WC2R 2LS London, UK.
  12. 12Department of Targeted Therapeutics, University of Twente, 7522 NB Enschede, Netherlands.
  13. 13Electron Microscopy Facility, RWTH Aachen University Hospital, 52074 Aachen, Germany.
  14. 14Institute of Molecular Biomedicine, Comenius University, 81972 Bratislava, Slovakia.
  1. Corresponding author. Email: pboor{at}ukaachen.de (P.B.); tlammers{at}ukaachen.de (T.L.)
  • * These authors equally contributed to this work.

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