Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development

Donghyun Kang; Jungkwon Shin; Yongsik Cho; Hyeon-Seop Kim; Young-Ran Gu; Haedong Kim; Kwon Tae You; Moon Jong Chang; Chong Bum Chang; Seung-Baik Kang; Jong-Seo Kim; V. Narry Kim; Jin-Hong Kim

doi:10.1126/scitranslmed.aar6659

Research ArticleOsteoarthritis

Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development

Donghyun Kang¹,²,*,
Jungkwon Shin¹,²,*,
Yongsik Cho¹,²,
Hyeon-Seop Kim¹,²,
Young-Ran Gu¹,²,
Haedong Kim¹,²,
Kwon Tae You¹,²,
Moon Jong Chang³,
Chong Bum Chang³,
Seung-Baik Kang³,
Jong-Seo Kim¹,²,
V. Narry Kim ¹,² and
Jin-Hong Kim ¹,²,⁴,†

¹Center for RNA Research, Institute for Basic Science, 08826 Seoul, South Korea.
²Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826 Seoul, South Korea.
³Department of Orthopedic Surgery, Seoul National University College of Medicine, Boramae Hospital, 07061 Seoul, South Korea.
⁴Interdisciplinary Program in Bioinformatics, Seoul National University, 08826 Seoul, South Korea.

↵†Corresponding author. Email: jinhkim{at}snu.ac.kr

↵* These authors contributed equally to this work.

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Science Translational Medicine 03 Apr 2019:
Vol. 11, Issue 486, eaar6659
DOI: 10.1126/scitranslmed.aar6659

Donghyun Kang

Center for RNA Research, Institute for Basic Science, 08826 Seoul, South Korea.Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826 Seoul, South Korea.

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Jungkwon Shin

Center for RNA Research, Institute for Basic Science, 08826 Seoul, South Korea.Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826 Seoul, South Korea.

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Yongsik Cho

Center for RNA Research, Institute for Basic Science, 08826 Seoul, South Korea.Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826 Seoul, South Korea.

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Hyeon-Seop Kim

Center for RNA Research, Institute for Basic Science, 08826 Seoul, South Korea.Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826 Seoul, South Korea.

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Young-Ran Gu

Center for RNA Research, Institute for Basic Science, 08826 Seoul, South Korea.Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826 Seoul, South Korea.

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Haedong Kim

Center for RNA Research, Institute for Basic Science, 08826 Seoul, South Korea.Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826 Seoul, South Korea.

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Kwon Tae You

Center for RNA Research, Institute for Basic Science, 08826 Seoul, South Korea.Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826 Seoul, South Korea.

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Moon Jong Chang

Department of Orthopedic Surgery, Seoul National University College of Medicine, Boramae Hospital, 07061 Seoul, South Korea.

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Chong Bum Chang

Department of Orthopedic Surgery, Seoul National University College of Medicine, Boramae Hospital, 07061 Seoul, South Korea.

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Seung-Baik Kang

Department of Orthopedic Surgery, Seoul National University College of Medicine, Boramae Hospital, 07061 Seoul, South Korea.

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Jong-Seo Kim

Center for RNA Research, Institute for Basic Science, 08826 Seoul, South Korea.Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826 Seoul, South Korea.

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V. Narry Kim

Center for RNA Research, Institute for Basic Science, 08826 Seoul, South Korea.Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826 Seoul, South Korea.

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Jin-Hong Kim

Center for RNA Research, Institute for Basic Science, 08826 Seoul, South Korea.Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826 Seoul, South Korea.Interdisciplinary Program in Bioinformatics, Seoul National University, 08826 Seoul, South Korea.

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ORCID record for Jin-Hong Kim
For correspondence: jinhkim@snu.ac.kr

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Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development

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