Research ArticleOsteoarthritis
Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development
- View ORCID ProfileDonghyun Kang1,2,*,
- View ORCID ProfileJungkwon Shin1,2,*,
- Yongsik Cho1,2,
- Hyeon-Seop Kim1,2,
- Young-Ran Gu1,2,
- View ORCID ProfileHaedong Kim1,2,
- Kwon Tae You1,2,
- Moon Jong Chang3,
- View ORCID ProfileChong Bum Chang3,
- Seung-Baik Kang3,
- View ORCID ProfileJong-Seo Kim1,2,
- View ORCID ProfileV. Narry Kim1,2 and
- View ORCID ProfileJin-Hong Kim1,2,4,†
- 1Center for RNA Research, Institute for Basic Science, 08826 Seoul, South Korea.
- 2Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826 Seoul, South Korea.
- 3Department of Orthopedic Surgery, Seoul National University College of Medicine, Boramae Hospital, 07061 Seoul, South Korea.
- 4Interdisciplinary Program in Bioinformatics, Seoul National University, 08826 Seoul, South Korea.
- ↵†Corresponding author. Email: jinhkim{at}snu.ac.kr
↵* These authors contributed equally to this work.
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Science Translational Medicine 03 Apr 2019:
Vol. 11, Issue 486, eaar6659
DOI: 10.1126/scitranslmed.aar6659
Vol. 11, Issue 486, eaar6659
DOI: 10.1126/scitranslmed.aar6659
Donghyun Kang
1Center for RNA Research, Institute for Basic Science, 08826 Seoul, South Korea.
2Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826 Seoul, South Korea.
Jungkwon Shin
1Center for RNA Research, Institute for Basic Science, 08826 Seoul, South Korea.
2Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826 Seoul, South Korea.
Yongsik Cho
1Center for RNA Research, Institute for Basic Science, 08826 Seoul, South Korea.
2Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826 Seoul, South Korea.
Hyeon-Seop Kim
1Center for RNA Research, Institute for Basic Science, 08826 Seoul, South Korea.
2Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826 Seoul, South Korea.
Young-Ran Gu
1Center for RNA Research, Institute for Basic Science, 08826 Seoul, South Korea.
2Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826 Seoul, South Korea.
Haedong Kim
1Center for RNA Research, Institute for Basic Science, 08826 Seoul, South Korea.
2Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826 Seoul, South Korea.
Kwon Tae You
1Center for RNA Research, Institute for Basic Science, 08826 Seoul, South Korea.
2Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826 Seoul, South Korea.
Moon Jong Chang
3Department of Orthopedic Surgery, Seoul National University College of Medicine, Boramae Hospital, 07061 Seoul, South Korea.
Chong Bum Chang
3Department of Orthopedic Surgery, Seoul National University College of Medicine, Boramae Hospital, 07061 Seoul, South Korea.
Seung-Baik Kang
3Department of Orthopedic Surgery, Seoul National University College of Medicine, Boramae Hospital, 07061 Seoul, South Korea.
Jong-Seo Kim
1Center for RNA Research, Institute for Basic Science, 08826 Seoul, South Korea.
2Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826 Seoul, South Korea.
V. Narry Kim
1Center for RNA Research, Institute for Basic Science, 08826 Seoul, South Korea.
2Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826 Seoul, South Korea.
Jin-Hong Kim
1Center for RNA Research, Institute for Basic Science, 08826 Seoul, South Korea.
2Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826 Seoul, South Korea.
4Interdisciplinary Program in Bioinformatics, Seoul National University, 08826 Seoul, South Korea.
