03 April 2019
Vol 11, Issue 486

About The Cover

Cover image expansion

ONLINE COVER A Smear Campaign. This image depicts an insoluble mucus flake with interspersed inflammatory cells recovered from a child with cystic fibrosis (CF). In patients with CF, airway abnormalities develop early in life and lead to irreversible damage. To elucidate the pathogenesis of the disease, Esther et al. analyzed bronchioalveolar lavage fluid and computed tomography images from children with CF. They found that accumulation of insoluble mucus flakes preceded structural lung alterations and bacterial infection. Early treatment with a mucolytic agent improved lung function in a sheep model of CF, suggesting that preventing mucus accumulation might be an effective strategy for treating early stage CF. [CREDIT: ESTHER ET AL./SCIENCE TRANSLATIONAL MEDICINE]