A pannexin 1 channelopathy causes human oocyte death

Qing Sang; Zhihua Zhang; Juanzi Shi; Xiaoxi Sun; Bin Li; Zheng Yan; Songguo Xue; Ai Ai; Qifeng Lyu; Wei Li; Jilin Zhang; Ling Wu; Xiaoyan Mao; Biaobang Chen; Jian Mu; Qiaoli Li; Jing Du; Qiang Sun; Li Jin; Lin He; Shujia Zhu; Yanping Kuang; Lei Wang

doi:10.1126/scitranslmed.aav8731

Research ArticleINFERTILITY

A pannexin 1 channelopathy causes human oocyte death

Qing Sang¹,*,†,
Zhihua Zhang¹,*,
Juanzi Shi²,*,
Xiaoxi Sun³,*,
Bin Li⁴,*,
Zheng Yan⁴,*,
Songguo Xue⁵,
Ai Ai⁴,
Qifeng Lyu⁴,
Wei Li⁶,
Jilin Zhang⁶,
Ling Wu⁴,
Xiaoyan Mao⁴,
Biaobang Chen¹,
Jian Mu¹,
Qiaoli Li¹,
Jing Du⁷,
Qiang Sun⁶,
Li Jin¹,
Lin He⁸,
Shujia Zhu⁶,
Yanping Kuang⁴,† and
Lei Wang ¹,⁹,†

¹Zhongshan Hospital, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
²Reproductive Medicine Center, Shaanxi Maternal and Child Care Service Center, Shaanxi 710069, China.
³Shanghai Ji Ai Genetics and IVF Institute, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China.
⁴Reproductive Medicine Center, Shanghai Ninth Hospital, Shanghai Jiao Tong University, Shanghai 200011, China.
⁵Reproductive Medicine Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 2000120, China.
⁶Institute of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
⁷Shanghai Institute of Planned Parenthood Research, Shanghai 200011, China.
⁸Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, China.
⁹Shanghai Center for Women and Children’s Health, Shanghai 200062, China.

↵†Corresponding author. Email: wangleiwanglei{at}fudan.edu.cn (L.W.); kuangyanp{at}126.com (Y.K.); sangqing{at}fudan.edu.cn (Q.S.)

↵* These authors contributed equally to this work.

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Science Translational Medicine 27 Mar 2019:
Vol. 11, Issue 485, eaav8731
DOI: 10.1126/scitranslmed.aav8731

Qing Sang

Zhongshan Hospital, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.

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ORCID record for Qing Sang
For correspondence: wangleiwanglei@fudan.edu.cn kuangyanp@126.com sangqing@fudan.edu.cn

Zhihua Zhang

Zhongshan Hospital, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.

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Juanzi Shi

Reproductive Medicine Center, Shaanxi Maternal and Child Care Service Center, Shaanxi 710069, China.

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Xiaoxi Sun

Shanghai Ji Ai Genetics and IVF Institute, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China.

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Bin Li

Reproductive Medicine Center, Shanghai Ninth Hospital, Shanghai Jiao Tong University, Shanghai 200011, China.

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Zheng Yan

Reproductive Medicine Center, Shanghai Ninth Hospital, Shanghai Jiao Tong University, Shanghai 200011, China.

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Songguo Xue

Reproductive Medicine Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 2000120, China.

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Ai Ai

Reproductive Medicine Center, Shanghai Ninth Hospital, Shanghai Jiao Tong University, Shanghai 200011, China.

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Qifeng Lyu

Reproductive Medicine Center, Shanghai Ninth Hospital, Shanghai Jiao Tong University, Shanghai 200011, China.

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Wei Li

Institute of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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Jilin Zhang

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Ling Wu

Reproductive Medicine Center, Shanghai Ninth Hospital, Shanghai Jiao Tong University, Shanghai 200011, China.

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Xiaoyan Mao

Reproductive Medicine Center, Shanghai Ninth Hospital, Shanghai Jiao Tong University, Shanghai 200011, China.

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Biaobang Chen

Zhongshan Hospital, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.

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Jian Mu

Zhongshan Hospital, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.

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Qiaoli Li

Zhongshan Hospital, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.

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Jing Du

Shanghai Institute of Planned Parenthood Research, Shanghai 200011, China.

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Qiang Sun

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Li Jin

Zhongshan Hospital, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.

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Lin He

Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, China.

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Shujia Zhu

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Yanping Kuang

Reproductive Medicine Center, Shanghai Ninth Hospital, Shanghai Jiao Tong University, Shanghai 200011, China.

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For correspondence: wangleiwanglei@fudan.edu.cn kuangyanp@126.com sangqing@fudan.edu.cn

Lei Wang

Zhongshan Hospital, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.Shanghai Center for Women and Children’s Health, Shanghai 200062, China.

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For correspondence: wangleiwanglei@fudan.edu.cn kuangyanp@126.com sangqing@fudan.edu.cn

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A pannexin 1 channelopathy causes human oocyte death

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