Research ArticleCancer Immunotherapy

GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells

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Science Translational Medicine  27 Mar 2019:
Vol. 11, Issue 485, eaau7746
DOI: 10.1126/scitranslmed.aau7746

Article Information

vol. 11 no. 485

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication July 19, 2018
  • Resubmitted December 14, 2018
  • Accepted for publication March 8, 2019
  • .

Author Information

  1. Eric L. Smith1,2,
  2. Kim Harrington3,
  3. Mette Staehr1,
  4. Reed Masakayan1,
  5. Jon Jones3,
  6. Thomas J. Long3,
  7. Khong Y. Ng4,
  8. Majid Ghoddusi3,
  9. Terence J. Purdon1,
  10. Xiuyan Wang5,
  11. Trevor Do3,
  12. Minh Thu Pham3,
  13. Jessica M. Brown3,
  14. Carlos Fernandez De Larrea1,6,
  15. Eric Olson3,
  16. Elizabeth Peguero4,
  17. Pei Wang7,
  18. Hong Liu7,
  19. Yiyang Xu7,
  20. Sarah C. Garrett-Thomson8,
  21. Steven C. Almo8,
  22. Hans-Guido Wendel4,
  23. Isabelle Riviere5,
  24. Cheng Liu7,
  25. Blythe Sather3 and
  26. Renier J. Brentjens1,9,*
  1. 1Cellular Therapeutics Center, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  2. 2Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  3. 3Juno Therapeutics, A Celgene Company, Seattle, WA 98109, USA.
  4. 4Sloan Kettering Institute, New York, NY 10065, USA.
  5. 5Cell Therapy and Cell Engineering Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  6. 6Amyloidosis and Myeloma Unit, Department of Hematology, Hospital Clinic, August Pi i Sunyer Biomedical Research Institute, University of Barcelona, 08036 Barcelona, Spain.
  7. 7Eureka Therapeutics, Emeryville, CA 94608, USA.
  8. 8Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  9. 9Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  1. *Corresponding author. Email: brentjer{at}mskcc.org

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Mar 201912448221075
Apr 201977221611092
May 2019565248219
Jun 2019419253148
Jul 2019435204150
Aug 2019422196100
Sep 201937213180