Research ArticleCancer Immunotherapy

GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells

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Science Translational Medicine  27 Mar 2019:
Vol. 11, Issue 485, eaau7746
DOI: 10.1126/scitranslmed.aau7746

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CARs to drive away multiple myeloma

Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer. These earlier CAR T cells targeted a protein called B cell maturation antigen, but some patients’ cancer cells expressed little to none of this antigen and were therefore resistant to the CAR T cells. Smith et al. identified another target antigen for multiple myeloma, called GPRC5D. The authors demonstrated that CAR T cells against GPRC5D are effective in mouse models, even those with tumors that are resistant to the earlier CARs, and they are safe in mice and primates.

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