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Research ArticleNeurodegenerative Disease
A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy
- View ORCID ProfileIsrael Hernandez1,*,
- Gabriel Luna1,*,
- Jennifer N. Rauch1,
- View ORCID ProfileSurya A. Reis2,
- View ORCID ProfileMichel Giroux1,
- View ORCID ProfileCeleste M. Karch3,
- Daniel Boctor1,
- View ORCID ProfileYoussef E. Sibih1,
- Nadia J. Storm4,
- Antonio Diaz4,
- View ORCID ProfileSusmita Kaushik4,
- Cezary Zekanowski5,
- View ORCID ProfileAlexander A. Kang1,
- Cassidy R. Hinman1,
- View ORCID ProfileVesna Cerovac1,
- Elmer Guzman1,
- View ORCID ProfileHonjun Zhou1,
- View ORCID ProfileStephen J. Haggarty2,
- Alison M. Goate6,
- Steven K. Fisher1,7,
- Ana M. Cuervo4 and
- View ORCID ProfileKenneth S. Kosik1,7,†
- 1Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
- 2Department of Neurology, Massachusetts General Hospital, Chemical Neurobiology Lab, and Center for Genomic Medicine, Harvard Medical School, Boston, MA 02114, USA.
- 3Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.
- 4Department of Developmental and Molecular Biology and Institute for Aging Studies, Albert Einstein College of Medicine, New York, NY 10461, USA.
- 5Laboratory of Neurogenetics, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego St., 02-106 Warsaw, Poland.
- 6Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
- 7Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
- ↵†Corresponding author. Email: kenneth.kosik{at}lifesci.ucsb.edu
↵* These authors contributed equally to this work.
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Science Translational Medicine 27 Mar 2019:
Vol. 11, Issue 485, eaat3005
DOI: 10.1126/scitranslmed.aat3005
Vol. 11, Issue 485, eaat3005
DOI: 10.1126/scitranslmed.aat3005
Israel Hernandez
1Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Gabriel Luna
1Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Jennifer N. Rauch
1Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Surya A. Reis
2Department of Neurology, Massachusetts General Hospital, Chemical Neurobiology Lab, and Center for Genomic Medicine, Harvard Medical School, Boston, MA 02114, USA.
Michel Giroux
1Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Celeste M. Karch
3Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.
Daniel Boctor
1Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Youssef E. Sibih
1Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Nadia J. Storm
4Department of Developmental and Molecular Biology and Institute for Aging Studies, Albert Einstein College of Medicine, New York, NY 10461, USA.
Antonio Diaz
4Department of Developmental and Molecular Biology and Institute for Aging Studies, Albert Einstein College of Medicine, New York, NY 10461, USA.
Susmita Kaushik
4Department of Developmental and Molecular Biology and Institute for Aging Studies, Albert Einstein College of Medicine, New York, NY 10461, USA.
Cezary Zekanowski
5Laboratory of Neurogenetics, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego St., 02-106 Warsaw, Poland.
Alexander A. Kang
1Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Cassidy R. Hinman
1Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Vesna Cerovac
1Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Elmer Guzman
1Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Honjun Zhou
1Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Stephen J. Haggarty
2Department of Neurology, Massachusetts General Hospital, Chemical Neurobiology Lab, and Center for Genomic Medicine, Harvard Medical School, Boston, MA 02114, USA.
Alison M. Goate
6Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Steven K. Fisher
1Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
7Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Ana M. Cuervo
4Department of Developmental and Molecular Biology and Institute for Aging Studies, Albert Einstein College of Medicine, New York, NY 10461, USA.
Kenneth S. Kosik
1Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
7Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
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