Research ArticleNeurodegenerative Disease

A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy

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Science Translational Medicine  27 Mar 2019:
Vol. 11, Issue 485, eaat3005
DOI: 10.1126/scitranslmed.aat3005

Article Information

vol. 11 no. 485

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  • Received for publication February 14, 2018
  • Resubmitted August 15, 2018
  • Accepted for publication November 30, 2018

Author Information

  1. Israel Hernandez1,*,
  2. Gabriel Luna1,*,
  3. Jennifer N. Rauch1,
  4. Surya A. Reis2,
  5. Michel Giroux1,
  6. Celeste M. Karch3,
  7. Daniel Boctor1,
  8. Youssef E. Sibih1,
  9. Nadia J. Storm4,
  10. Antonio Diaz4,
  11. Susmita Kaushik4,
  12. Cezary Zekanowski5,
  13. Alexander A. Kang1,
  14. Cassidy R. Hinman1,
  15. Vesna Cerovac1,
  16. Elmer Guzman1,
  17. Honjun Zhou1,
  18. Stephen J. Haggarty2,
  19. Alison M. Goate6,
  20. Steven K. Fisher1,7,
  21. Ana M. Cuervo4 and
  22. Kenneth S. Kosik1,7,
  1. 1Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
  2. 2Department of Neurology, Massachusetts General Hospital, Chemical Neurobiology Lab, and Center for Genomic Medicine, Harvard Medical School, Boston, MA 02114, USA.
  3. 3Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.
  4. 4Department of Developmental and Molecular Biology and Institute for Aging Studies, Albert Einstein College of Medicine, New York, NY 10461, USA.
  5. 5Laboratory of Neurogenetics, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego St., 02-106 Warsaw, Poland.
  6. 6Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  7. 7Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
  1. Corresponding author. Email: kenneth.kosik{at}
  • * These authors contributed equally to this work.


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Article usage: March 2019 to April 2019

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Apr 20193100695590