Focus10TH ANNIVERSARY SERIES

Advances in artificial pancreas systems

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Science Translational Medicine  20 Mar 2019:
Vol. 11, Issue 484, eaaw4949
DOI: 10.1126/scitranslmed.aaw4949

Figures

  • Fig. 1 Closed-loop artificial pancreas systems.

    (A) Diagram depicting closed-loop insulin delivery. A continuous glucose monitor (CGM) worn subcutaneously transmits information about interstitial glucose concentrations to a smartphone or other control algorithm device (CAD), which hosts a control algorithm that translates information from the CGM and computes the amount of insulin to deliver. An insulin pump delivers rapid-acting insulin analog subcutaneously. Insulin delivery is modulated in real time by the control algorithm. Communication between system components is wireless. (B) Schematic depicting where the components of a closed-loop insulin delivery system may be worn and held by a human subject with type 1 diabetes.

    CREDIT: A. KITTERMAN/SCIENCE TRANSLATIONAL MEDICINE

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