A cytochrome P450 allele confers pyrethroid resistance on a major African malaria vector, reducing insecticide-treated bednet efficacy

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Science Translational Medicine  20 Mar 2019:
Vol. 11, Issue 484, eaat7386
DOI: 10.1126/scitranslmed.aat7386

Article Information

vol. 11 no. 484

Print ISSN: 
Online ISSN: 
  • Received for publication March 29, 2018
  • Accepted for publication October 9, 2018
  • .

Author Information

  1. Gareth D. Weedall1,2,
  2. Leon M. J. Mugenzi3,4,
  3. Benjamin D. Menze1,3,4,
  4. Magellan Tchouakui3,4,
  5. Sulaiman S. Ibrahim1,5,
  6. Nathalie Amvongo-Adjia4,6,
  7. Helen Irving1,
  8. Murielle J. Wondji1,3,4,
  9. Micareme Tchoupo3,4,
  10. Rousseau Djouaka7,
  11. Jacob M. Riveron1,3,4 and
  12. Charles S. Wondji1,3,4,*
  1. 1Department of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.
  2. 2School of Natural Sciences and Psychology, Liverpool John Moores University, Liverpool L3 3AF, U.K.
  3. 3LSTM Research Unit at the Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), P.O. Box 288, Yaoundé, Cameroon.
  4. 4Centre for Research in Infectious Diseases (CRID), P.O. Box 13591, Yaoundé, Cameroon.
  5. 5Department of Biochemistry, Bayero University, PMB 3011, Kano, Nigeria.
  6. 6Centre for Medical Research, Institute of Medical Research and Medicinal Plants Studies (IMPM), P.O. Box 13033, Yaoundé, Cameroon.
  7. 7International Institute of Tropical Agriculture (IITA), Cotonou 08 BP 0932, Benin.
  1. *Corresponding author. Email: charles.wondji{at}


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