An antibody-drug conjugate directed to the ALK receptor demonstrates efficacy in preclinical models of neuroblastoma

Renata Sano; Kateryna Krytska; Colleen E. Larmour; Pichai Raman; Daniel Martinez; Gwenda F. Ligon; Jay S. Lillquist; Ulisse Cucchi; Paolo Orsini; Simona Rizzi; Bruce R. Pawel; Diego Alvarado; Yael P. Mossé

doi:10.1126/scitranslmed.aau9732

Research ArticleCancer

An antibody-drug conjugate directed to the ALK receptor demonstrates efficacy in preclinical models of neuroblastoma

Renata Sano¹,
Kateryna Krytska¹,
Colleen E. Larmour¹,
Pichai Raman²,
Daniel Martinez³,
Gwenda F. Ligon⁴,
Jay S. Lillquist⁴,
Ulisse Cucchi⁵,
Paolo Orsini⁵,
Simona Rizzi⁵,
Bruce R. Pawel³,
Diego Alvarado⁴ and
Yael P. Mossé ¹,⁶,*

¹Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
²Division of Oncology and Center for Biomedical Informatics (CBMi), Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
³Department of Pathology, Children’s Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
⁴Celldex Therapeutics Inc., New Haven, CT 06511, USA.
⁵Nerviano Medical Sciences S.r.l., Nerviano (MI) 20014, Italy.
⁶Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

↵*Corresponding author. Email: mosse{at}chop.edu

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Science Translational Medicine 13 Mar 2019:
Vol. 11, Issue 483, eaau9732
DOI: 10.1126/scitranslmed.aau9732

Renata Sano

Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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ORCID record for Renata Sano

Kateryna Krytska

Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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Colleen E. Larmour

Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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Pichai Raman

Division of Oncology and Center for Biomedical Informatics (CBMi), Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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ORCID record for Pichai Raman

Daniel Martinez

Department of Pathology, Children’s Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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Gwenda F. Ligon

Celldex Therapeutics Inc., New Haven, CT 06511, USA.

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Jay S. Lillquist

Celldex Therapeutics Inc., New Haven, CT 06511, USA.

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Ulisse Cucchi

Nerviano Medical Sciences S.r.l., Nerviano (MI) 20014, Italy.

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Paolo Orsini

Nerviano Medical Sciences S.r.l., Nerviano (MI) 20014, Italy.

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Simona Rizzi

Nerviano Medical Sciences S.r.l., Nerviano (MI) 20014, Italy.

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Bruce R. Pawel

Department of Pathology, Children’s Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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Diego Alvarado

Celldex Therapeutics Inc., New Haven, CT 06511, USA.

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Yael P. Mossé

Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

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For correspondence: mosse@chop.edu

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An antibody-drug conjugate directed to the ALK receptor demonstrates efficacy in preclinical models of neuroblastoma

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