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Research ArticleCancer
An antibody-drug conjugate directed to the ALK receptor demonstrates efficacy in preclinical models of neuroblastoma
- View ORCID ProfileRenata Sano1,
- Kateryna Krytska1,
- Colleen E. Larmour1,
- View ORCID ProfilePichai Raman2,
- View ORCID ProfileDaniel Martinez3,
- Gwenda F. Ligon4,
- Jay S. Lillquist4,
- Ulisse Cucchi5,
- Paolo Orsini5,
- View ORCID ProfileSimona Rizzi5,
- View ORCID ProfileBruce R. Pawel3,
- View ORCID ProfileDiego Alvarado4 and
- Yael P. Mossé1,6,*
- 1Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
- 2Division of Oncology and Center for Biomedical Informatics (CBMi), Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
- 3Department of Pathology, Children’s Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
- 4Celldex Therapeutics Inc., New Haven, CT 06511, USA.
- 5Nerviano Medical Sciences S.r.l., Nerviano (MI) 20014, Italy.
- 6Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
- ↵*Corresponding author. Email: mosse{at}chop.edu
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Science Translational Medicine 13 Mar 2019:
Vol. 11, Issue 483, eaau9732
DOI: 10.1126/scitranslmed.aau9732
Vol. 11, Issue 483, eaau9732
DOI: 10.1126/scitranslmed.aau9732
Renata Sano
1Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Kateryna Krytska
1Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Colleen E. Larmour
1Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Pichai Raman
2Division of Oncology and Center for Biomedical Informatics (CBMi), Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Daniel Martinez
3Department of Pathology, Children’s Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Gwenda F. Ligon
4Celldex Therapeutics Inc., New Haven, CT 06511, USA.
Jay S. Lillquist
4Celldex Therapeutics Inc., New Haven, CT 06511, USA.
Ulisse Cucchi
5Nerviano Medical Sciences S.r.l., Nerviano (MI) 20014, Italy.
Paolo Orsini
5Nerviano Medical Sciences S.r.l., Nerviano (MI) 20014, Italy.
Simona Rizzi
5Nerviano Medical Sciences S.r.l., Nerviano (MI) 20014, Italy.
Bruce R. Pawel
3Department of Pathology, Children’s Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Diego Alvarado
4Celldex Therapeutics Inc., New Haven, CT 06511, USA.
Yael P. Mossé
1Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
6Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
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