ReportDrug Delivery
A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment
- View ORCID ProfileMalvika Verma1,2,3,
- View ORCID ProfileKaran Vishwanath2,
- Feyisope Eweje2,4,5,
- View ORCID ProfileNiclas Roxhed2,6,
- Tyler Grant2,7,*,
- Macy Castaneda2,
- View ORCID ProfileChristoph Steiger2,5,7,
- View ORCID ProfileHormoz Mazdiyasni2,7,
- Taylor Bensel2,7,
- View ORCID ProfileDaniel Minahan2,7,†,
- View ORCID ProfileVance Soares2,7,
- John A. F. Salama2,
- Aaron Lopes2,7,
- View ORCID ProfileKaitlyn Hess2,7,
- View ORCID ProfileCody Cleveland2,7,
- View ORCID ProfileDaniel J. Fulop2,
- View ORCID ProfileAlison Hayward2,7,8,
- View ORCID ProfileJoy Collins2,7,
- Siddartha M. Tamang2,7,
- Tiffany Hua2,7,
- Chinonyelum Ikeanyi2,4,
- View ORCID ProfileGal Zeidman2,4,
- View ORCID ProfileElizabeth Mule2,7,
- Sooraj Boominathan2,9,
- View ORCID ProfileEllena Popova2,10,
- View ORCID ProfileJonathan B. Miller4,11,
- Andrew M. Bellinger2,7,12,*,
- View ORCID ProfileDavid Collins13,14,
- Dalia Leibowitz3,4,
- Shelly Batra15,
- Sandeep Ahuja15,
- Manju Bajiya15,
- View ORCID ProfileSonali Batra15,
- Rohit Sarin16,
- Upasna Agarwal16,
- Sunil D. Khaparde17,
- Neeraj K. Gupta18,
- Deepak Gupta19,
- View ORCID ProfileAnuj K. Bhatnagar20,
- Kamal K. Chopra21,
- Nandini Sharma22,
- Ashwani Khanna23,
- Jayeeta Chowdhury24,
- Robert Stoner3,25,
- Alexander H. Slocum3,4,
- View ORCID ProfileMichael J. Cima2,3,26,
- View ORCID ProfileJennifer Furin27,
- View ORCID ProfileRobert Langer1,2,3,4,7,28,29,‡ and
- View ORCID ProfileGiovanni Traverso2,3,4,5,7,‡
- 1Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 3Tata Center for Technology and Design, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 4Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 5Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
- 6Department of Micro and Nanosystems, KTH Royal Institute of Technology, Stockholm 10044, Sweden.
- 7Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 8Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 9Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 10Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 11Sloan School of Management, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 12Cardiovascular Division, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
- 13Management Sciences for Health, Medford, MA 02155, USA.
- 14Boston University School of Public Health, Boston, MA 02118, USA.
- 15Operation ASHA, New Delhi 110076, India.
- 16National Institute of Tuberculosis and Respiratory Diseases, New Delhi 110030, India.
- 17Former Deputy Director General and Head of Central TB Division, Government of India, New Delhi 110011, India.
- 18Department of Respiratory Medicine, Safdarjung Hospital, New Delhi 110029, India.
- 19Division of Pulmonary and Critical Care Medicine, All India Institute of Medical Sciences, New Delhi 110029, India.
- 20Rajan Babu Institute for Pulmonary Medicine and Tuberculosis, New Delhi 110009, India.
- 21New Delhi Tuberculosis Centre, New Delhi 110002, India.
- 22Department of Community Medicine, Maulana Azad Medical College, New Delhi 110002, India.
- 23Lok Nayak Hospital Chest Clinic, New Delhi 110002, India.
- 24Tata Trusts, Mumbai 400001, India.
- 25MIT Energy Initiative, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 26Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 27Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA 02115, USA.
- 28Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 29Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- ↵‡Corresponding author. Email: rlanger{at}mit.edu (R.L.); ctraverso{at}bwh.harvard.edu, cgt20{at}mit.edu (G.T.)
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Science Translational Medicine 13 Mar 2019:
Vol. 11, Issue 483, eaau6267
DOI: 10.1126/scitranslmed.aau6267
Vol. 11, Issue 483, eaau6267
DOI: 10.1126/scitranslmed.aau6267
Malvika Verma
1Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
3Tata Center for Technology and Design, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Karan Vishwanath
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Feyisope Eweje
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
4Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
5Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Niclas Roxhed
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
6Department of Micro and Nanosystems, KTH Royal Institute of Technology, Stockholm 10044, Sweden.
Tyler Grant
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
7Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Macy Castaneda
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Christoph Steiger
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
5Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
7Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Hormoz Mazdiyasni
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
7Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Taylor Bensel
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
7Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Daniel Minahan
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
7Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Vance Soares
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
7Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
John A. F. Salama
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Aaron Lopes
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
7Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Kaitlyn Hess
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
7Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Cody Cleveland
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
7Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Daniel J. Fulop
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Alison Hayward
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
7Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
8Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Joy Collins
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
7Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Siddartha M. Tamang
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
7Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Tiffany Hua
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
7Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Chinonyelum Ikeanyi
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
4Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Gal Zeidman
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
4Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Elizabeth Mule
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
7Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Sooraj Boominathan
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
9Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Ellena Popova
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
10Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Jonathan B. Miller
4Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
11Sloan School of Management, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Andrew M. Bellinger
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
7Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
12Cardiovascular Division, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
David Collins
13Management Sciences for Health, Medford, MA 02155, USA.
14Boston University School of Public Health, Boston, MA 02118, USA.
Dalia Leibowitz
3Tata Center for Technology and Design, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
4Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Shelly Batra
15Operation ASHA, New Delhi 110076, India.
Sandeep Ahuja
15Operation ASHA, New Delhi 110076, India.
Manju Bajiya
15Operation ASHA, New Delhi 110076, India.
Sonali Batra
15Operation ASHA, New Delhi 110076, India.
Rohit Sarin
16National Institute of Tuberculosis and Respiratory Diseases, New Delhi 110030, India.
Upasna Agarwal
16National Institute of Tuberculosis and Respiratory Diseases, New Delhi 110030, India.
Sunil D. Khaparde
17Former Deputy Director General and Head of Central TB Division, Government of India, New Delhi 110011, India.
Neeraj K. Gupta
18Department of Respiratory Medicine, Safdarjung Hospital, New Delhi 110029, India.
Deepak Gupta
19Division of Pulmonary and Critical Care Medicine, All India Institute of Medical Sciences, New Delhi 110029, India.
Anuj K. Bhatnagar
20Rajan Babu Institute for Pulmonary Medicine and Tuberculosis, New Delhi 110009, India.
Kamal K. Chopra
21New Delhi Tuberculosis Centre, New Delhi 110002, India.
Nandini Sharma
22Department of Community Medicine, Maulana Azad Medical College, New Delhi 110002, India.
Ashwani Khanna
23Lok Nayak Hospital Chest Clinic, New Delhi 110002, India.
Jayeeta Chowdhury
24Tata Trusts, Mumbai 400001, India.
Robert Stoner
3Tata Center for Technology and Design, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
25MIT Energy Initiative, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Alexander H. Slocum
3Tata Center for Technology and Design, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
4Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Michael J. Cima
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
3Tata Center for Technology and Design, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
26Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Jennifer Furin
27Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA 02115, USA.
Robert Langer
1Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
3Tata Center for Technology and Design, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
4Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
7Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
28Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
29Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Giovanni Traverso
2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
3Tata Center for Technology and Design, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
4Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
5Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
7Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
