ReportDrug Delivery
A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment
- Malvika Verma1,2,3,
- Karan Vishwanath2,
- Feyisope Eweje2,4,5,
- Niclas Roxhed2,6,
- Tyler Grant2,7,*,
- Macy Castaneda2,
- Christoph Steiger2,5,7,
- Hormoz Mazdiyasni2,7,
- Taylor Bensel2,7,
- Daniel Minahan2,7,†,
- Vance Soares2,7,
- John A. F. Salama2,
- Aaron Lopes2,7,
- Kaitlyn Hess2,7,
- Cody Cleveland2,7,
- Daniel J. Fulop2,
- Alison Hayward2,7,8,
- Joy Collins2,7,
- Siddartha M. Tamang2,7,
- Tiffany Hua2,7,
- Chinonyelum Ikeanyi2,4,
- Gal Zeidman2,4,
- Elizabeth Mule2,7,
- Sooraj Boominathan2,9,
- Ellena Popova2,10,
- Jonathan B. Miller4,11,
- Andrew M. Bellinger2,7,12,*,
- David Collins13,14,
- Dalia Leibowitz3,4,
- Shelly Batra15,
- Sandeep Ahuja15,
- Manju Bajiya15,
- Sonali Batra15,
- Rohit Sarin16,
- Upasna Agarwal16,
- Sunil D. Khaparde17,
- Neeraj K. Gupta18,
- Deepak Gupta19,
- Anuj K. Bhatnagar20,
- Kamal K. Chopra21,
- Nandini Sharma22,
- Ashwani Khanna23,
- Jayeeta Chowdhury24,
- Robert Stoner3,25,
- Alexander H. Slocum3,4,
- Michael J. Cima2,3,26,
- Jennifer Furin27,
- Robert Langer1,2,3,4,7,28,29,‡ and
- Giovanni Traverso2,3,4,5,7,‡
- 1Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 3Tata Center for Technology and Design, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 4Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 5Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
- 6Department of Micro and Nanosystems, KTH Royal Institute of Technology, Stockholm 10044, Sweden.
- 7Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 8Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 9Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 10Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 11Sloan School of Management, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 12Cardiovascular Division, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
- 13Management Sciences for Health, Medford, MA 02155, USA.
- 14Boston University School of Public Health, Boston, MA 02118, USA.
- 15Operation ASHA, New Delhi 110076, India.
- 16National Institute of Tuberculosis and Respiratory Diseases, New Delhi 110030, India.
- 17Former Deputy Director General and Head of Central TB Division, Government of India, New Delhi 110011, India.
- 18Department of Respiratory Medicine, Safdarjung Hospital, New Delhi 110029, India.
- 19Division of Pulmonary and Critical Care Medicine, All India Institute of Medical Sciences, New Delhi 110029, India.
- 20Rajan Babu Institute for Pulmonary Medicine and Tuberculosis, New Delhi 110009, India.
- 21New Delhi Tuberculosis Centre, New Delhi 110002, India.
- 22Department of Community Medicine, Maulana Azad Medical College, New Delhi 110002, India.
- 23Lok Nayak Hospital Chest Clinic, New Delhi 110002, India.
- 24Tata Trusts, Mumbai 400001, India.
- 25MIT Energy Initiative, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 26Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 27Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA 02115, USA.
- 28Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 29Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- ↵‡Corresponding author. Email: rlanger{at}mit.edu (R.L.); ctraverso{at}bwh.harvard.edu, cgt20{at}mit.edu (G.T.)
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Science Translational Medicine 13 Mar 2019:
Vol. 11, Issue 483, eaau6267
DOI: 10.1126/scitranslmed.aau6267
Vol. 11, Issue 483, eaau6267
DOI: 10.1126/scitranslmed.aau6267
Malvika Verma
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Tata Center for Technology and Design, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Karan Vishwanath
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Feyisope Eweje
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Niclas Roxhed
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Micro and Nanosystems, KTH Royal Institute of Technology, Stockholm 10044, Sweden.
Tyler Grant
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Macy Castaneda
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Christoph Steiger
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Hormoz Mazdiyasni
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Taylor Bensel
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Daniel Minahan
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Vance Soares
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
John A. F. Salama
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Aaron Lopes
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Kaitlyn Hess
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Cody Cleveland
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Daniel J. Fulop
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Alison Hayward
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Joy Collins
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Siddartha M. Tamang
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Tiffany Hua
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Chinonyelum Ikeanyi
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Gal Zeidman
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Elizabeth Mule
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Sooraj Boominathan
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Ellena Popova
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Jonathan B. Miller
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Sloan School of Management, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Andrew M. Bellinger
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Cardiovascular Division, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
David Collins
Management Sciences for Health, Medford, MA 02155, USA.Boston University School of Public Health, Boston, MA 02118, USA.
Dalia Leibowitz
Tata Center for Technology and Design, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Shelly Batra
Operation ASHA, New Delhi 110076, India.
Sandeep Ahuja
Operation ASHA, New Delhi 110076, India.
Manju Bajiya
Operation ASHA, New Delhi 110076, India.
Sonali Batra
Operation ASHA, New Delhi 110076, India.
Rohit Sarin
National Institute of Tuberculosis and Respiratory Diseases, New Delhi 110030, India.
Upasna Agarwal
National Institute of Tuberculosis and Respiratory Diseases, New Delhi 110030, India.
Sunil D. Khaparde
Former Deputy Director General and Head of Central TB Division, Government of India, New Delhi 110011, India.
Neeraj K. Gupta
Department of Respiratory Medicine, Safdarjung Hospital, New Delhi 110029, India.
Deepak Gupta
Division of Pulmonary and Critical Care Medicine, All India Institute of Medical Sciences, New Delhi 110029, India.
Anuj K. Bhatnagar
Rajan Babu Institute for Pulmonary Medicine and Tuberculosis, New Delhi 110009, India.
Kamal K. Chopra
New Delhi Tuberculosis Centre, New Delhi 110002, India.
Nandini Sharma
Department of Community Medicine, Maulana Azad Medical College, New Delhi 110002, India.
Ashwani Khanna
Lok Nayak Hospital Chest Clinic, New Delhi 110002, India.
Jayeeta Chowdhury
Tata Trusts, Mumbai 400001, India.
Robert Stoner
Tata Center for Technology and Design, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.MIT Energy Initiative, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Alexander H. Slocum
Tata Center for Technology and Design, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Michael J. Cima
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Tata Center for Technology and Design, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Jennifer Furin
Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA 02115, USA.
Robert Langer
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Tata Center for Technology and Design, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Giovanni Traverso
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Tata Center for Technology and Design, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
