ReportDrug Delivery

A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment

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Science Translational Medicine  13 Mar 2019:
Vol. 11, Issue 483, eaau6267
DOI: 10.1126/scitranslmed.aau6267

Dependable drug delivery

Although Mycobacterium tuberculosis (TB) infections are effectively treated with antibiotics, treatment requiring multigram dosing can pose considerable challenges for patients in resource-constrained environments. Here, Verma et al. developed a drug delivery system that is compatible with nasogastric administration consisting of bead-like drug pills on a shape memory wire that resides in the stomach for long-term, multigram dosing. The device was administered to healthy pigs where it demonstrated safe, sustained antibiotic release within the stomach over weeks; it was also easily retrieved from the stomach when drug delivery was complete. The authors suggest that this device could improve patients’ adherence to treatment regimens.

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