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ZEB1 suppression sensitizes KRAS mutant cancers to MEK inhibition by an IL17RD-dependent mechanism

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Science Translational Medicine  13 Mar 2019:
Vol. 11, Issue 483, eaaq1238
DOI: 10.1126/scitranslmed.aaq1238

Article Information

vol. 11 no. 483

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication October 3, 2017
  • Resubmitted August 20, 2018
  • Accepted for publication February 18, 2019
  • .

Author Information

  1. David H. Peng1,2,
  2. Samrat T. Kundu1,
  3. Jared J. Fradette1,
  4. Lixia Diao3,
  5. Pan Tong3,
  6. Lauren A. Byers1,
  7. Jing Wang3,
  8. Jaime Rodriguez Canales4,
  9. Pamela A. Villalobos4,
  10. Barbara Mino4,
  11. Yanan Yang5,
  12. Rosalba Minelli6,
  13. Michael D. Peoples6,7,
  14. Christopher A. Bristow6,7,
  15. Timothy P. Heffernan6,7,
  16. Alessandro Carugo6,7,
  17. Ignacio I. Wistuba4 and
  18. Don L. Gibbons1,8,*
  1. 1Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  2. 2University of Texas Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
  3. 3Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  4. 4Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  5. 5Thoracic Disease Research Unit, Division of Pulmonary and Critical Care Medicine and Department of Biochemistry and Molecular Biology, Cancer Center and College of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
  6. 6Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  7. 7Institute for Applied Cancer Science, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  8. 8Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  1. *Corresponding author. Email: dlgibbon{at}mdanderson.org

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