Editors' ChoiceCARDIOMYOPATHY

Genomic reorganization underlies LMNA-associated cardiomyopathies

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Science Translational Medicine  06 Mar 2019:
Vol. 11, Issue 482, eaaw7627
DOI: 10.1126/scitranslmed.aaw7627

Abstract

Mutations in LMNA result in dilated cardiomyopathy through disruption of chromatin organization, methylation, and aberrant gene expression.

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