Research ArticleCardiology

Activin type II receptor signaling in cardiac aging and heart failure

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Science Translational Medicine  06 Mar 2019:
Vol. 11, Issue 482, eaau8680
DOI: 10.1126/scitranslmed.aau8680

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  • RE: ActRII may be Increased by Loss of Testosterone

    I suggest the findings of Roh, et al., may be explained by the loss of testosterone with aging. A case may be made in the literature that ActRII is increased with androgen. Activin is also negatively associated with testosterone. Additionally, a case may also be made within the literature that, actually, heart disease of aging results from the natural loss of testosterone.

    Competing Interests: None declared.