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Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth

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Science Translational Medicine  06 Mar 2019:
Vol. 11, Issue 482, eaau5612
DOI: 10.1126/scitranslmed.aau5612

Article Information

vol. 11 no. 482

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication June 22, 2018
  • Accepted for publication February 7, 2019
  • .

Author Information

  1. Troy E. Messick1,*,
  2. Garry R. Smith2,
  3. Samantha S. Soldan1,
  4. Mark E. McDonnell2,3,
  5. Julianna S. Deakyne1,
  6. Kimberly A. Malecka1,
  7. Lois Tolvinski1,
  8. A. Pieter J. van den Heuvel3,
  9. Bai-Wei Gu3,
  10. Joel A. Cassel3,
  11. Donna H. Tran1,
  12. Benjamin R. Wassermann1,
  13. Yan Zhang2,
  14. Venkata Velvadapu2,
  15. Edward R. Zartler4,
  16. Pierre Busson5,
  17. Allen B. Reitz2 and
  18. Paul M. Lieberman1,*
  1. 1The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.
  2. 2Fox Chase Chemical Diversity Center Inc., 3805 Old Easton Road, Doylestown, PA 18902, USA.
  3. 3Vironika LLC, 3624 Market Street, Ste 5E, Philadelphia, PA 19104, USA.
  4. 4Quantum Tessera Consulting LLC, 508 Tawnyberry Lane, Collegeville, PA 19426, USA.
  5. 5Institut Gustave Roussy, 114 Rue Edouard Vaillant, 84800 Villejuif, France.
  1. *Corresponding author. Email: lieberman{at}wistar.org (P.M.L.); troymessick{at}gmail.com (T.E.M.)

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Mar 20194724861484
Apr 20192549182
May 20192358879
Jun 20192103344
Jul 20191245256
Aug 20191145852
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Oct 20191354646
Nov 2019551515