Contents
06 March 2019
Vol 11, Issue 482
Vol 11, Issue 482
Research Articles
- PAI-1 augments mucosal damage in colitis
SERPINE1/PAI-1 is elevated in the colon tissue of the most difficult-to-treat patients with IBD and leads to worsening of experimental colitis.
- Activin type II receptor signaling in cardiac aging and heart failure
Activin type II receptor signaling regulates cardiac function in aging and heart failure by modulating proteasome-dependent SERCA2a degradation.
- Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth
EBNA1 inhibitors developed by fragment-based drug design block EBNA1 DNA binding and EBV-dependent tumor cell growth in vivo.
- Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus
CD19-targeted CAR T cells show sustained CD19+ B cell depletion and profound therapeutic benefit in ameliorating disease in mouse models of lupus.
Review
- Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier
This Review discusses invasive and noninvasive therapeutic delivery methods to the inner ear and challenges presented by the blood-labyrinth barrier.
Editors' Choice
- Nature versus nurture in autism
Structural MRI study of twins with autism reveals both genetic and environmental factors contribute to abnormal neural growth patterns.
- Genomic reorganization underlies LMNA-associated cardiomyopathies
Mutations in LMNA result in dilated cardiomyopathy through disruption of chromatin organization, methylation, and aberrant gene expression.
- Aging T cells portend poor outcome in follicular lymphoma
Immune cell profiling identifies intratumoral T cell subsets associated with patient survival in follicular lymphoma.
About The Cover
ONLINE COVER A Punch to the Gut by PAI-1. Not all patients with inflammatory bowel disease (IBD) respond well to therapy. To find new drug targets that could help such patients, Kaiko et al. examined gene networks in several large cohorts of patients with IBD and found increased expression of genes associated with blood coagulation in patients with severe disease. This gut biopsy from an individual with difficult-to-treat ulcerative colitis (a form of IBD) shows expression of PAI-1 (red), a component of the coagulation cascade. Inhibition of PAI-1 alleviated symptoms in mouse models of colitis by promoting healing of the gut mucosa, suggesting that targeting PAI-1 may bring relief to patients with severe IBD. [CREDIT: KAIKO ET AL./SCIENCE TRANSLATIONAL MEDICINE]
