06 March 2019
Vol 11, Issue 482

About The Cover

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ONLINE COVER A Punch to the Gut by PAI-1. Not all patients with inflammatory bowel disease (IBD) respond well to therapy. To find new drug targets that could help such patients, Kaiko et al. examined gene networks in several large cohorts of patients with IBD and found increased expression of genes associated with blood coagulation in patients with severe disease. This gut biopsy from an individual with difficult-to-treat ulcerative colitis (a form of IBD) shows expression of PAI-1 (red), a component of the coagulation cascade. Inhibition of PAI-1 alleviated symptoms in mouse models of colitis by promoting healing of the gut mucosa, suggesting that targeting PAI-1 may bring relief to patients with severe IBD. [CREDIT: KAIKO ET AL./SCIENCE TRANSLATIONAL MEDICINE]