Focus10TH ANNIVERSARY SERIES

Driving CAR T cell translation forward

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Science Translational Medicine  27 Feb 2019:
Vol. 11, Issue 481, eaaw2127
DOI: 10.1126/scitranslmed.aaw2127

Figures

  • Fig. 1 Progress in CAR T cell therapy.

    Success in early CAR T cell clinical trials propelled rapid evolution of the field from small early-phase trials to FDA approval of commercialized cell products within a decade. Continued progress will require solutions to biological challenges, including barriers that have limited the efficacy of CAR T cells in non–B cell malignancies, as well as addressing the manufacturing challenges currently limiting accessibility of these therapies for patients.

    CREDIT: A. KITTERMAN/SCIENCE TRANSLATIONAL MEDICINE

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