Targeting the NF-κB signaling pathway in chronic tendon disease

Adam C. Abraham; Shivam A. Shah; Mikhail Golman; Lee Song; Xiaoning Li; Iden Kurtaliaj; Moeed Akbar; Neal L. Millar; Yousef Abu-Amer; Leesa M. Galatz; Stavros Thomopoulos

doi:10.1126/scitranslmed.aav4319

Research ArticleTENDINOPATHY

Targeting the NF-κB signaling pathway in chronic tendon disease

Adam C. Abraham¹,*,
Shivam A. Shah²,*,
Mikhail Golman³,
Lee Song¹,
Xiaoning Li¹,
Iden Kurtaliaj³,
Moeed Akbar⁴,
Neal L. Millar ⁴,
Yousef Abu-Amer⁵,⁶,
Leesa M. Galatz⁷ and
Stavros Thomopoulos ¹,³,†

¹Department of Orthopedic Surgery, Columbia University, 650 W 168th St, New York, NY 10032, USA.
²Department of Biomedical Engineering, Washington University in St. Louis, 1 Brookings Drive, St. Louis, MO 63130, USA.
³Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Ave, New York, NY 10027, USA.
⁴Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary and Life Sciences, University of Glasgow, 120 University Ave., Glasgow, Scotland G12 8TA, UK.
⁵Departments of Orthopedic Surgery and Cell Biology and Physiology, Washington University in St. Louis, 660 S. Euclid Ave., St. Louis, MO 63110, USA.
⁶Shriners Hospital for Children, 4400 Clayton Ave, St. Louis, MO 63110, USA.
⁷Department of Orthopedic Surgery, Mount Sinai, 5 E 98th St., New York, NY 10029, USA.

↵†Corresponding author. Email: sat2{at}columbia.edu

↵* These authors contributed equally to this work.

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Science Translational Medicine 27 Feb 2019:
Vol. 11, Issue 481, eaav4319
DOI: 10.1126/scitranslmed.aav4319

Adam C. Abraham

Department of Orthopedic Surgery, Columbia University, 650 W 168th St, New York, NY 10032, USA.

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Shivam A. Shah

Department of Biomedical Engineering, Washington University in St. Louis, 1 Brookings Drive, St. Louis, MO 63130, USA.

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Mikhail Golman

Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Ave, New York, NY 10027, USA.

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Lee Song

Department of Orthopedic Surgery, Columbia University, 650 W 168th St, New York, NY 10032, USA.

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Xiaoning Li

Department of Orthopedic Surgery, Columbia University, 650 W 168th St, New York, NY 10032, USA.

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Iden Kurtaliaj

Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Ave, New York, NY 10027, USA.

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Moeed Akbar

Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary and Life Sciences, University of Glasgow, 120 University Ave., Glasgow, Scotland G12 8TA, UK.

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Neal L. Millar

Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary and Life Sciences, University of Glasgow, 120 University Ave., Glasgow, Scotland G12 8TA, UK.

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Yousef Abu-Amer

Departments of Orthopedic Surgery and Cell Biology and Physiology, Washington University in St. Louis, 660 S. Euclid Ave., St. Louis, MO 63110, USA.

Shriners Hospital for Children, 4400 Clayton Ave, St. Louis, MO 63110, USA.

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Leesa M. Galatz

Department of Orthopedic Surgery, Mount Sinai, 5 E 98th St., New York, NY 10029, USA.

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Stavros Thomopoulos

Department of Orthopedic Surgery, Columbia University, 650 W 168th St, New York, NY 10032, USA.

Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Ave, New York, NY 10027, USA.

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For correspondence: sat2@columbia.edu

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Inhibition of IKKβ/NF-κB in stromal cells prevents degeneration and improves healing, representing a potential therapeutic for chronic tendinopathy.

Targeting the NF-κB signaling pathway in chronic tendon disease

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