Research ArticleAutism Spectrum Disorder
Patients with autism spectrum disorders display reproducible functional connectivity alterations
- View ORCID ProfileŠtefan Holiga1,*,
- View ORCID ProfileJoerg F. Hipp1,
- Christopher H. Chatham1,
- View ORCID ProfilePilar Garces1,
- Will Spooren1,
- Xavier Liogier D’Ardhuy1,
- Alessandro Bertolino1,2,
- Céline Bouquet1,
- View ORCID ProfileJan K. Buitelaar3,
- View ORCID ProfileCarsten Bours3,
- Annika Rausch3,
- Marianne Oldehinkel3,4,
- View ORCID ProfileManuel Bouvard5,
- View ORCID ProfileAnouck Amestoy5,
- Mireille Caralp6,
- Sonia Gueguen7,
- View ORCID ProfileMyriam Ly-Le Moal8,
- Josselin Houenou9,10,
- Christian F. Beckmann3,
- Eva Loth11,
- View ORCID ProfileDeclan Murphy11,
- View ORCID ProfileTony Charman11,
- View ORCID ProfileJulian Tillmann11,12,
- Charles Laidi9,
- Richard Delorme13,14,
- View ORCID ProfileAnita Beggiato13,14,
- View ORCID ProfileAlexandru Gaman9,
- View ORCID ProfileIsabelle Scheid9,
- Marion Leboyer9,
- Marc-Antoine d’Albis9,10,
- View ORCID ProfileJeff Sevigny1,
- View ORCID ProfileChristian Czech1,
- Federico Bolognani1,15,
- Garry D. Honey1 and
- View ORCID ProfileJuergen Dukart1,16,17,*
- 1Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
- 2Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari ‘Aldo Moro’, 70121 Bari, Italy.
- 3Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen Medical center, Nijmegen 6525 EN, Netherlands.
- 4Brain & Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences and School of Psychological Sciences, Monash University, Clayton, VIC 3800, Australia.
- 5Pôle Universitaire de Psychiatrie de l'Enfant et de l'Adolescent, Hôpital Charles Perrens Bordeaux, 33076 Bordeaux, France.
- 6INSERM, National Biobank Infrastructure, 75013 Paris, France.
- 7INSERM, Clinical Research Department, 75014 Paris, France.
- 8Institut Roche, 92100 Boulogne-Billancourt, France.
- 9Hôpitaux Universitaires Mondor, DHU PePSY, Pôle de psychiatrie, Faculté de Médecine, Université Paris Est, INSERM U955, IMRB, Equipe 15, Psychiatrie Translationnelle, Fondation FondaMental, 94000 Créteil, France.
- 10NeuroSpin, UNIACT Lab, Psychiatry Team, CEA Saclay, 91191 Gif-Sur-Yvette, France.
- 11Institute of Psychiatry, Psychology & Neuroscience, King’s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.
- 12Department of Applied Psychology: Health, Development, Enhancement, and Intervention, University of Vienna, 1010 Vienna, Austria.
- 13APHP, Robert Debré Hospital, Child and Adolescent Psychiatry Department, Paris, France.
- 14Pasteur Institute, 75019 Paris, France.
- 15Therachon AG, Aeschenvorstadt 36, 4051 Basel, Switzerland.
- 16Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, 52428 Jülich, Germany.
- 17Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, 40223 Düsseldorf, Germany.
- ↵*Corresponding author. Email: juergen.dukart{at}gmail.com (J.D.); stefan.holiga{at}roche.com (S.H.)
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Science Translational Medicine 27 Feb 2019:
Vol. 11, Issue 481, eaat9223
DOI: 10.1126/scitranslmed.aat9223
Vol. 11, Issue 481, eaat9223
DOI: 10.1126/scitranslmed.aat9223
Štefan Holiga
1Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
Joerg F. Hipp
1Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
Christopher H. Chatham
1Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
Pilar Garces
1Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
Will Spooren
1Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
Xavier Liogier D’Ardhuy
1Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
Alessandro Bertolino
1Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
2Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari ‘Aldo Moro’, 70121 Bari, Italy.
Céline Bouquet
1Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
Jan K. Buitelaar
3Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen Medical center, Nijmegen 6525 EN, Netherlands.
Carsten Bours
3Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen Medical center, Nijmegen 6525 EN, Netherlands.
Annika Rausch
3Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen Medical center, Nijmegen 6525 EN, Netherlands.
Marianne Oldehinkel
3Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen Medical center, Nijmegen 6525 EN, Netherlands.
4Brain & Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences and School of Psychological Sciences, Monash University, Clayton, VIC 3800, Australia.
Manuel Bouvard
5Pôle Universitaire de Psychiatrie de l'Enfant et de l'Adolescent, Hôpital Charles Perrens Bordeaux, 33076 Bordeaux, France.
Anouck Amestoy
5Pôle Universitaire de Psychiatrie de l'Enfant et de l'Adolescent, Hôpital Charles Perrens Bordeaux, 33076 Bordeaux, France.
Mireille Caralp
6INSERM, National Biobank Infrastructure, 75013 Paris, France.
Sonia Gueguen
7INSERM, Clinical Research Department, 75014 Paris, France.
Myriam Ly-Le Moal
8Institut Roche, 92100 Boulogne-Billancourt, France.
Josselin Houenou
9Hôpitaux Universitaires Mondor, DHU PePSY, Pôle de psychiatrie, Faculté de Médecine, Université Paris Est, INSERM U955, IMRB, Equipe 15, Psychiatrie Translationnelle, Fondation FondaMental, 94000 Créteil, France.
10NeuroSpin, UNIACT Lab, Psychiatry Team, CEA Saclay, 91191 Gif-Sur-Yvette, France.
Christian F. Beckmann
3Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen Medical center, Nijmegen 6525 EN, Netherlands.
Eva Loth
11Institute of Psychiatry, Psychology & Neuroscience, King’s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.
Declan Murphy
11Institute of Psychiatry, Psychology & Neuroscience, King’s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.
Tony Charman
11Institute of Psychiatry, Psychology & Neuroscience, King’s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.
Julian Tillmann
11Institute of Psychiatry, Psychology & Neuroscience, King’s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.
12Department of Applied Psychology: Health, Development, Enhancement, and Intervention, University of Vienna, 1010 Vienna, Austria.
Charles Laidi
9Hôpitaux Universitaires Mondor, DHU PePSY, Pôle de psychiatrie, Faculté de Médecine, Université Paris Est, INSERM U955, IMRB, Equipe 15, Psychiatrie Translationnelle, Fondation FondaMental, 94000 Créteil, France.
Richard Delorme
13APHP, Robert Debré Hospital, Child and Adolescent Psychiatry Department, Paris, France.
14Pasteur Institute, 75019 Paris, France.
Anita Beggiato
13APHP, Robert Debré Hospital, Child and Adolescent Psychiatry Department, Paris, France.
14Pasteur Institute, 75019 Paris, France.
Alexandru Gaman
9Hôpitaux Universitaires Mondor, DHU PePSY, Pôle de psychiatrie, Faculté de Médecine, Université Paris Est, INSERM U955, IMRB, Equipe 15, Psychiatrie Translationnelle, Fondation FondaMental, 94000 Créteil, France.
Isabelle Scheid
9Hôpitaux Universitaires Mondor, DHU PePSY, Pôle de psychiatrie, Faculté de Médecine, Université Paris Est, INSERM U955, IMRB, Equipe 15, Psychiatrie Translationnelle, Fondation FondaMental, 94000 Créteil, France.
Marion Leboyer
9Hôpitaux Universitaires Mondor, DHU PePSY, Pôle de psychiatrie, Faculté de Médecine, Université Paris Est, INSERM U955, IMRB, Equipe 15, Psychiatrie Translationnelle, Fondation FondaMental, 94000 Créteil, France.
Marc-Antoine d’Albis
9Hôpitaux Universitaires Mondor, DHU PePSY, Pôle de psychiatrie, Faculté de Médecine, Université Paris Est, INSERM U955, IMRB, Equipe 15, Psychiatrie Translationnelle, Fondation FondaMental, 94000 Créteil, France.
10NeuroSpin, UNIACT Lab, Psychiatry Team, CEA Saclay, 91191 Gif-Sur-Yvette, France.
Jeff Sevigny
1Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
Christian Czech
1Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
Federico Bolognani
1Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
15Therachon AG, Aeschenvorstadt 36, 4051 Basel, Switzerland.
Garry D. Honey
1Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
Juergen Dukart
1Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
16Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, 52428 Jülich, Germany.
17Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, 40223 Düsseldorf, Germany.
