Patients with autism spectrum disorders display reproducible functional connectivity alterations

Štefan Holiga; Joerg F. Hipp; Christopher H. Chatham; Pilar Garces; Will Spooren; Xavier Liogier D’Ardhuy; Alessandro Bertolino; Céline Bouquet; Jan K. Buitelaar; Carsten Bours; Annika Rausch; Marianne Oldehinkel; Manuel Bouvard; Anouck Amestoy; Mireille Caralp; Sonia Gueguen; Myriam Ly-Le Moal; Josselin Houenou; Christian F. Beckmann; Eva Loth; Declan Murphy; Tony Charman; Julian Tillmann; Charles Laidi; Richard Delorme; Anita Beggiato; Alexandru Gaman; Isabelle Scheid; Marion Leboyer; Marc-Antoine d’Albis; Jeff Sevigny; Christian Czech; Federico Bolognani; Garry D. Honey; Juergen Dukart

doi:10.1126/scitranslmed.aat9223

Research ArticleAutism Spectrum Disorder

Patients with autism spectrum disorders display reproducible functional connectivity alterations

Štefan Holiga¹,*,
Joerg F. Hipp¹,
Christopher H. Chatham¹,
Pilar Garces¹,
Will Spooren¹,
Xavier Liogier D’Ardhuy¹,
Alessandro Bertolino¹,²,
Céline Bouquet¹,
Jan K. Buitelaar³,
Carsten Bours³,
Annika Rausch³,
Marianne Oldehinkel³,⁴,
Manuel Bouvard⁵,
Anouck Amestoy⁵,
Mireille Caralp⁶,
Sonia Gueguen⁷,
Myriam Ly-Le Moal⁸,
Josselin Houenou⁹,¹⁰,
Christian F. Beckmann³,
Eva Loth¹¹,
Declan Murphy¹¹,
Tony Charman¹¹,
Julian Tillmann¹¹,¹²,
Charles Laidi⁹,
Richard Delorme¹³,¹⁴,
Anita Beggiato¹³,¹⁴,
Alexandru Gaman⁹,
Isabelle Scheid⁹,
Marion Leboyer⁹,
Marc-Antoine d’Albis⁹,¹⁰,
Jeff Sevigny¹,
Christian Czech¹,
Federico Bolognani¹,¹⁵,
Garry D. Honey¹ and
Juergen Dukart¹,¹⁶,¹⁷,*

¹Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
²Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari ‘Aldo Moro’, 70121 Bari, Italy.
³Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen Medical center, Nijmegen 6525 EN, Netherlands.
⁴Brain & Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences and School of Psychological Sciences, Monash University, Clayton, VIC 3800, Australia.
⁵Pôle Universitaire de Psychiatrie de l'Enfant et de l'Adolescent, Hôpital Charles Perrens Bordeaux, 33076 Bordeaux, France.
⁶INSERM, National Biobank Infrastructure, 75013 Paris, France.
⁷INSERM, Clinical Research Department, 75014 Paris, France.
⁸Institut Roche, 92100 Boulogne-Billancourt, France.
⁹Hôpitaux Universitaires Mondor, DHU PePSY, Pôle de psychiatrie, Faculté de Médecine, Université Paris Est, INSERM U955, IMRB, Equipe 15, Psychiatrie Translationnelle, Fondation FondaMental, 94000 Créteil, France.
¹⁰NeuroSpin, UNIACT Lab, Psychiatry Team, CEA Saclay, 91191 Gif-Sur-Yvette, France.
¹¹Institute of Psychiatry, Psychology & Neuroscience, King’s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.
¹²Department of Applied Psychology: Health, Development, Enhancement, and Intervention, University of Vienna, 1010 Vienna, Austria.
¹³APHP, Robert Debré Hospital, Child and Adolescent Psychiatry Department, Paris, France.
¹⁴Pasteur Institute, 75019 Paris, France.
¹⁵Therachon AG, Aeschenvorstadt 36, 4051 Basel, Switzerland.
¹⁶Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, 52428 Jülich, Germany.
¹⁷Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, 40223 Düsseldorf, Germany.

↵*Corresponding author. Email: juergen.dukart{at}gmail.com (J.D.); stefan.holiga{at}roche.com (S.H.)

See allHide authors and affiliations

Science Translational Medicine 27 Feb 2019:
Vol. 11, Issue 481, eaat9223
DOI: 10.1126/scitranslmed.aat9223

Štefan Holiga

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Štefan Holiga
For correspondence: juergen.dukart@gmail.com stefan.holiga@roche.com

Joerg F. Hipp

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Joerg F. Hipp

Christopher H. Chatham

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Pilar Garces

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Pilar Garces

Will Spooren

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Xavier Liogier D’Ardhuy

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Alessandro Bertolino

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari ‘Aldo Moro’, 70121 Bari, Italy.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Céline Bouquet

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jan K. Buitelaar

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jan K. Buitelaar

Carsten Bours

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Carsten Bours

Annika Rausch

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Marianne Oldehinkel

Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen Medical center, Nijmegen 6525 EN, Netherlands.Brain & Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences and School of Psychological Sciences, Monash University, Clayton, VIC 3800, Australia.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Manuel Bouvard

Pôle Universitaire de Psychiatrie de l'Enfant et de l'Adolescent, Hôpital Charles Perrens Bordeaux, 33076 Bordeaux, France.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Manuel Bouvard

Anouck Amestoy

Pôle Universitaire de Psychiatrie de l'Enfant et de l'Adolescent, Hôpital Charles Perrens Bordeaux, 33076 Bordeaux, France.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Anouck Amestoy

Mireille Caralp

INSERM, National Biobank Infrastructure, 75013 Paris, France.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Sonia Gueguen

INSERM, Clinical Research Department, 75014 Paris, France.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Myriam Ly-Le Moal

Institut Roche, 92100 Boulogne-Billancourt, France.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Myriam Ly-Le Moal

Josselin Houenou

Hôpitaux Universitaires Mondor, DHU PePSY, Pôle de psychiatrie, Faculté de Médecine, Université Paris Est, INSERM U955, IMRB, Equipe 15, Psychiatrie Translationnelle, Fondation FondaMental, 94000 Créteil, France.NeuroSpin, UNIACT Lab, Psychiatry Team, CEA Saclay, 91191 Gif-Sur-Yvette, France.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Christian F. Beckmann

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Eva Loth

Institute of Psychiatry, Psychology & Neuroscience, King’s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Declan Murphy

Institute of Psychiatry, Psychology & Neuroscience, King’s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Declan Murphy

Tony Charman

Institute of Psychiatry, Psychology & Neuroscience, King’s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Tony Charman

Julian Tillmann

Institute of Psychiatry, Psychology & Neuroscience, King’s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.Department of Applied Psychology: Health, Development, Enhancement, and Intervention, University of Vienna, 1010 Vienna, Austria.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Julian Tillmann

Charles Laidi

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Richard Delorme

APHP, Robert Debré Hospital, Child and Adolescent Psychiatry Department, Paris, France.Pasteur Institute, 75019 Paris, France.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Anita Beggiato

APHP, Robert Debré Hospital, Child and Adolescent Psychiatry Department, Paris, France.Pasteur Institute, 75019 Paris, France.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Anita Beggiato

Alexandru Gaman

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Alexandru Gaman

Isabelle Scheid

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Isabelle Scheid

Marion Leboyer

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Marc-Antoine d’Albis

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jeff Sevigny

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jeff Sevigny

Christian Czech

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Christian Czech

Federico Bolognani

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.Therachon AG, Aeschenvorstadt 36, 4051 Basel, Switzerland.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Garry D. Honey

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Juergen Dukart

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, 52428 Jülich, Germany.Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, 40223 Düsseldorf, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Juergen Dukart
For correspondence: juergen.dukart@gmail.com stefan.holiga@roche.com

Article
Figures & Data
Info & Metrics
eLetters
PDF

Log in to view PDF

via AAAS login

AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have purchased individual subscriptions.

Become an AAAS Member
Activate your Account
Purchase Access to Other Journals in the Science Family
Account Help

Log in through your institution

More options

Purchase digital access to this article

Download and print this article for your personal scholarly, research, and educational use.

Purchase this issue in print

Buy a single issue of Science for just $15 USD.

View Full Text

Patients with autism spectrum disorders display reproducible functional connectivity alterations

Log in to view PDF

Log in through your institution

Log in through your institution

More options

Science Translational Medicine

Article Tools