Patients with autism spectrum disorders display reproducible functional connectivity alterations

Štefan Holiga; Joerg F. Hipp; Christopher H. Chatham; Pilar Garces; Will Spooren; Xavier Liogier D’Ardhuy; Alessandro Bertolino; Céline Bouquet; Jan K. Buitelaar; Carsten Bours; Annika Rausch; Marianne Oldehinkel; Manuel Bouvard; Anouck Amestoy; Mireille Caralp; Sonia Gueguen; Myriam Ly-Le Moal; Josselin Houenou; Christian F. Beckmann; Eva Loth; Declan Murphy; Tony Charman; Julian Tillmann; Charles Laidi; Richard Delorme; Anita Beggiato; Alexandru Gaman; Isabelle Scheid; Marion Leboyer; Marc-Antoine d’Albis; Jeff Sevigny; Christian Czech; Federico Bolognani; Garry D. Honey; Juergen Dukart

doi:10.1126/scitranslmed.aat9223

Research ArticleAutism Spectrum Disorder

Patients with autism spectrum disorders display reproducible functional connectivity alterations

Štefan Holiga¹,*,
Joerg F. Hipp¹,
Christopher H. Chatham¹,
Pilar Garces¹,
Will Spooren¹,
Xavier Liogier D’Ardhuy¹,
Alessandro Bertolino¹,²,
Céline Bouquet¹,
Jan K. Buitelaar³,
Carsten Bours³,
Annika Rausch³,
Marianne Oldehinkel³,⁴,
Manuel Bouvard⁵,
Anouck Amestoy⁵,
Mireille Caralp⁶,
Sonia Gueguen⁷,
Myriam Ly-Le Moal⁸,
Josselin Houenou⁹,¹⁰,
Christian F. Beckmann³,
Eva Loth¹¹,
Declan Murphy¹¹,
Tony Charman¹¹,
Julian Tillmann¹¹,¹²,
Charles Laidi⁹,
Richard Delorme¹³,¹⁴,
Anita Beggiato¹³,¹⁴,
Alexandru Gaman⁹,
Isabelle Scheid⁹,
Marion Leboyer⁹,
Marc-Antoine d’Albis⁹,¹⁰,
Jeff Sevigny¹,
Christian Czech¹,
Federico Bolognani¹,¹⁵,
Garry D. Honey¹ and
Juergen Dukart¹,¹⁶,¹⁷,*

¹Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
²Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari ‘Aldo Moro’, 70121 Bari, Italy.
³Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen Medical center, Nijmegen 6525 EN, Netherlands.
⁴Brain & Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences and School of Psychological Sciences, Monash University, Clayton, VIC 3800, Australia.
⁵Pôle Universitaire de Psychiatrie de l'Enfant et de l'Adolescent, Hôpital Charles Perrens Bordeaux, 33076 Bordeaux, France.
⁶INSERM, National Biobank Infrastructure, 75013 Paris, France.
⁷INSERM, Clinical Research Department, 75014 Paris, France.
⁸Institut Roche, 92100 Boulogne-Billancourt, France.
⁹Hôpitaux Universitaires Mondor, DHU PePSY, Pôle de psychiatrie, Faculté de Médecine, Université Paris Est, INSERM U955, IMRB, Equipe 15, Psychiatrie Translationnelle, Fondation FondaMental, 94000 Créteil, France.
¹⁰NeuroSpin, UNIACT Lab, Psychiatry Team, CEA Saclay, 91191 Gif-Sur-Yvette, France.
¹¹Institute of Psychiatry, Psychology & Neuroscience, King’s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.
¹²Department of Applied Psychology: Health, Development, Enhancement, and Intervention, University of Vienna, 1010 Vienna, Austria.
¹³APHP, Robert Debré Hospital, Child and Adolescent Psychiatry Department, Paris, France.
¹⁴Pasteur Institute, 75019 Paris, France.
¹⁵Therachon AG, Aeschenvorstadt 36, 4051 Basel, Switzerland.
¹⁶Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, 52428 Jülich, Germany.
¹⁷Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, 40223 Düsseldorf, Germany.

↵*Corresponding author. Email: juergen.dukart{at}gmail.com (J.D.); stefan.holiga{at}roche.com (S.H.)

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Science Translational Medicine 27 Feb 2019:
Vol. 11, Issue 481, eaat9223
DOI: 10.1126/scitranslmed.aat9223

Štefan Holiga

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.

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ORCID record for Štefan Holiga
For correspondence: juergen.dukart@gmail.com stefan.holiga@roche.com

Joerg F. Hipp

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.

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Christopher H. Chatham

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.

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Pilar Garces

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.

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Will Spooren

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.

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Xavier Liogier D’Ardhuy

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.

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Alessandro Bertolino

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari ‘Aldo Moro’, 70121 Bari, Italy.

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Céline Bouquet

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.

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Jan K. Buitelaar

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Carsten Bours

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Annika Rausch

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Marianne Oldehinkel

Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen Medical center, Nijmegen 6525 EN, Netherlands.Brain & Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences and School of Psychological Sciences, Monash University, Clayton, VIC 3800, Australia.

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Manuel Bouvard

Pôle Universitaire de Psychiatrie de l'Enfant et de l'Adolescent, Hôpital Charles Perrens Bordeaux, 33076 Bordeaux, France.

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Anouck Amestoy

Pôle Universitaire de Psychiatrie de l'Enfant et de l'Adolescent, Hôpital Charles Perrens Bordeaux, 33076 Bordeaux, France.

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Mireille Caralp

INSERM, National Biobank Infrastructure, 75013 Paris, France.

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Sonia Gueguen

INSERM, Clinical Research Department, 75014 Paris, France.

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Myriam Ly-Le Moal

Institut Roche, 92100 Boulogne-Billancourt, France.

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Josselin Houenou

Hôpitaux Universitaires Mondor, DHU PePSY, Pôle de psychiatrie, Faculté de Médecine, Université Paris Est, INSERM U955, IMRB, Equipe 15, Psychiatrie Translationnelle, Fondation FondaMental, 94000 Créteil, France.NeuroSpin, UNIACT Lab, Psychiatry Team, CEA Saclay, 91191 Gif-Sur-Yvette, France.

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Christian F. Beckmann

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Eva Loth

Institute of Psychiatry, Psychology & Neuroscience, King’s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.

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Declan Murphy

Institute of Psychiatry, Psychology & Neuroscience, King’s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.

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Tony Charman

Institute of Psychiatry, Psychology & Neuroscience, King’s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.

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Julian Tillmann

Institute of Psychiatry, Psychology & Neuroscience, King’s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.Department of Applied Psychology: Health, Development, Enhancement, and Intervention, University of Vienna, 1010 Vienna, Austria.

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Charles Laidi

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Richard Delorme

APHP, Robert Debré Hospital, Child and Adolescent Psychiatry Department, Paris, France.Pasteur Institute, 75019 Paris, France.

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Anita Beggiato

APHP, Robert Debré Hospital, Child and Adolescent Psychiatry Department, Paris, France.Pasteur Institute, 75019 Paris, France.

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Alexandru Gaman

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Isabelle Scheid

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Marion Leboyer

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Marc-Antoine d’Albis

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Jeff Sevigny

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.

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Christian Czech

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.

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Federico Bolognani

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.Therachon AG, Aeschenvorstadt 36, 4051 Basel, Switzerland.

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Garry D. Honey

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.

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Juergen Dukart

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, 52428 Jülich, Germany.Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, 40223 Düsseldorf, Germany.

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For correspondence: juergen.dukart@gmail.com stefan.holiga@roche.com

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