Research ArticleAutism Spectrum Disorder

Patients with autism spectrum disorders display reproducible functional connectivity alterations

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Science Translational Medicine  27 Feb 2019:
Vol. 11, Issue 481, eaat9223
DOI: 10.1126/scitranslmed.aat9223

Article Information

vol. 11 no. 481

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History: 
  • Received for publication April 18, 2018
  • Resubmitted November 22, 2018
  • Accepted for publication February 5, 2019
  • .

Author Information

  1. Štefan Holiga1,*,
  2. Joerg F. Hipp1,
  3. Christopher H. Chatham1,
  4. Pilar Garces1,
  5. Will Spooren1,
  6. Xavier Liogier D’Ardhuy1,
  7. Alessandro Bertolino1,2,
  8. Céline Bouquet1,
  9. Jan K. Buitelaar3,
  10. Carsten Bours3,
  11. Annika Rausch3,
  12. Marianne Oldehinkel3,4,
  13. Manuel Bouvard5,
  14. Anouck Amestoy5,
  15. Mireille Caralp6,
  16. Sonia Gueguen7,
  17. Myriam Ly-Le Moal8,
  18. Josselin Houenou9,10,
  19. Christian F. Beckmann3,
  20. Eva Loth11,
  21. Declan Murphy11,
  22. Tony Charman11,
  23. Julian Tillmann11,12,
  24. Charles Laidi9,
  25. Richard Delorme13,14,
  26. Anita Beggiato13,14,
  27. Alexandru Gaman9,
  28. Isabelle Scheid9,
  29. Marion Leboyer9,
  30. Marc-Antoine d’Albis9,10,
  31. Jeff Sevigny1,
  32. Christian Czech1,
  33. Federico Bolognani1,15,
  34. Garry D. Honey1 and
  35. Juergen Dukart1,16,17,*
  1. 1Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
  2. 2Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari ‘Aldo Moro’, 70121 Bari, Italy.
  3. 3Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen Medical center, Nijmegen 6525 EN, Netherlands.
  4. 4Brain & Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences and School of Psychological Sciences, Monash University, Clayton, VIC 3800, Australia.
  5. 5Pôle Universitaire de Psychiatrie de l'Enfant et de l'Adolescent, Hôpital Charles Perrens Bordeaux, 33076 Bordeaux, France.
  6. 6INSERM, National Biobank Infrastructure, 75013 Paris, France.
  7. 7INSERM, Clinical Research Department, 75014 Paris, France.
  8. 8Institut Roche, 92100 Boulogne-Billancourt, France.
  9. 9Hôpitaux Universitaires Mondor, DHU PePSY, Pôle de psychiatrie, Faculté de Médecine, Université Paris Est, INSERM U955, IMRB, Equipe 15, Psychiatrie Translationnelle, Fondation FondaMental, 94000 Créteil, France.
  10. 10NeuroSpin, UNIACT Lab, Psychiatry Team, CEA Saclay, 91191 Gif-Sur-Yvette, France.
  11. 11Institute of Psychiatry, Psychology & Neuroscience, King’s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.
  12. 12Department of Applied Psychology: Health, Development, Enhancement, and Intervention, University of Vienna, 1010 Vienna, Austria.
  13. 13APHP, Robert Debré Hospital, Child and Adolescent Psychiatry Department, Paris, France.
  14. 14Pasteur Institute, 75019 Paris, France.
  15. 15Therachon AG, Aeschenvorstadt 36, 4051 Basel, Switzerland.
  16. 16Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, 52428 Jülich, Germany.
  17. 17Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, 40223 Düsseldorf, Germany.
  1. *Corresponding author. Email: juergen.dukart{at}gmail.com (J.D.); stefan.holiga{at}roche.com (S.H.)

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