Research ArticleAutism Spectrum Disorder

Patients with autism spectrum disorders display reproducible functional connectivity alterations

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Science Translational Medicine  27 Feb 2019:
Vol. 11, Issue 481, eaat9223
DOI: 10.1126/scitranslmed.aat9223

Connecting the dots in autism

Multiple studies have shown that patients with autism spectrum disorder (ASD) present alteration in brain functional connectivity; however, the heterogeneity of the findings and the lack of replication in independent cohorts hindered the emergence of a general consensus on the nature and clinical relevance of these changes. Now, Holiga et al. used resting-state functional magnetic resonance imaging to evaluate functional connectivity in four independent cohorts of patients with ASD. The authors identified functional connectivity alterations that were conserved across cohorts and partially correlated with clinical symptoms. Deciphering brain connectivity alterations in ASD might help the development of better diagnostic and therapeutic tools.

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