Shaping of infant B cell receptor repertoires by environmental factors and infectious disease

Sandra C. A. Nielsen; Krishna M. Roskin; Katherine J. L. Jackson; Shilpa A. Joshi; Parastu Nejad; Ji-Yeun Lee; Lisa E. Wagar; Tho D. Pham; Ramona A. Hoh; Khoa D. Nguyen; Hannah Y. Tsunemoto; Sonal B. Patel; Robert Tibshirani; Catherine Ley; Mark M. Davis; Julie Parsonnet; Scott D. Boyd

doi:10.1126/scitranslmed.aat2004

Research ArticleADAPTIVE IMMUNITY

Shaping of infant B cell receptor repertoires by environmental factors and infectious disease

Sandra C. A. Nielsen ¹,*,
Krishna M. Roskin¹,²,³,*,
Katherine J. L. Jackson¹,⁴,
Shilpa A. Joshi¹,
Parastu Nejad¹,
Ji-Yeun Lee¹,
Lisa E. Wagar⁵,
Tho D. Pham¹,⁶,
Ramona A. Hoh¹,
Khoa D. Nguyen¹,
Hannah Y. Tsunemoto¹,
Sonal B. Patel¹,
Robert Tibshirani⁷,⁸,
Catherine Ley⁹,
Mark M. Davis⁵,¹⁰,
Julie Parsonnet⁹,¹¹,† and
Scott D. Boyd ¹,†

¹Department of Pathology, Stanford University, Stanford, CA 94305, USA.
²Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45229, USA.
³Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.
⁴Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
⁵Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
⁶Stanford Blood Center, Palo Alto, CA 94304, USA.
⁷Department of Biomedical Data Sciences, Stanford University, Stanford, CA 94305, USA.
⁸Department of Statistics, Stanford University, Stanford, CA 94305, USA.
⁹Department of Medicine, Stanford University, Stanford, CA 94305, USA.
¹⁰Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
¹¹Department of Health Research and Policy, Stanford University, Stanford, CA 94305, USA.

↵†Corresponding author. Email: sboyd1{at}stanford.edu (S.D.B.); parsonnt{at}stanford.edu (J.P.)

↵* These authors contributed equally to this work.

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Science Translational Medicine 27 Feb 2019:
Vol. 11, Issue 481, eaat2004
DOI: 10.1126/scitranslmed.aat2004

Sandra C. A. Nielsen

1Department of Pathology, Stanford University, Stanford, CA 94305, USA.

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Krishna M. Roskin

1Department of Pathology, Stanford University, Stanford, CA 94305, USA.

2Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45229, USA.

3Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.

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Katherine J. L. Jackson

1Department of Pathology, Stanford University, Stanford, CA 94305, USA.

4Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.

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Shilpa A. Joshi

1Department of Pathology, Stanford University, Stanford, CA 94305, USA.

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Parastu Nejad

1Department of Pathology, Stanford University, Stanford, CA 94305, USA.

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Ji-Yeun Lee

1Department of Pathology, Stanford University, Stanford, CA 94305, USA.

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Lisa E. Wagar

5Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.

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Tho D. Pham

1Department of Pathology, Stanford University, Stanford, CA 94305, USA.

6Stanford Blood Center, Palo Alto, CA 94304, USA.

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Ramona A. Hoh

1Department of Pathology, Stanford University, Stanford, CA 94305, USA.

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Khoa D. Nguyen

1Department of Pathology, Stanford University, Stanford, CA 94305, USA.

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Hannah Y. Tsunemoto

1Department of Pathology, Stanford University, Stanford, CA 94305, USA.

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Sonal B. Patel

1Department of Pathology, Stanford University, Stanford, CA 94305, USA.

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Robert Tibshirani

7Department of Biomedical Data Sciences, Stanford University, Stanford, CA 94305, USA.

8Department of Statistics, Stanford University, Stanford, CA 94305, USA.

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Catherine Ley

9Department of Medicine, Stanford University, Stanford, CA 94305, USA.

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Mark M. Davis

5Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.

10Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.

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Julie Parsonnet

9Department of Medicine, Stanford University, Stanford, CA 94305, USA.

11Department of Health Research and Policy, Stanford University, Stanford, CA 94305, USA.

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For correspondence: sboyd1@stanford.edu parsonnt@stanford.edu

Scott D. Boyd

1Department of Pathology, Stanford University, Stanford, CA 94305, USA.

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For correspondence: sboyd1@stanford.edu parsonnt@stanford.edu

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Shaping of infant B cell receptor repertoires by environmental factors and infectious disease

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