Research ArticleALLERGY

The nonlesional skin surface distinguishes atopic dermatitis with food allergy as a unique endotype

See allHide authors and affiliations

Science Translational Medicine  20 Feb 2019:
Vol. 11, Issue 480, eaav2685
DOI: 10.1126/scitranslmed.aav2685

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Digging skin deep

Disrupted epithelial barriers are thought to be central to development of allergic disorders such as atopic dermatitis, which is commonly associated with food allergy. Leung et al. performed repeated skin tape stripping on lesional and nonlesional skin of patients with pediatric atopic dermatitis, some of whom also had food allergies. Among other parameters, they measured lipids, proteins, barrier integrity, and the microbiome. They found that nonlesional skin from patients with atopic dermatitis had different characteristics depending on whether the patient also had food allergy. Gene expression analysis also showed elevated type 2 immune signatures in food allergic samples. Their findings reveal unique properties about the epidermis in allergic disease and could lead to the development of biomarkers for food allergy.