Sodium chloride is an ionic checkpoint for human TH2 cells and shapes the atopic skin microenvironment

Julia Matthias; Julia Maul; Rebecca Noster; Hanna Meinl; Ying-Yin Chao; Heiko Gerstenberg; Florian Jeschke; Gilles Gasparoni; Anna Welle; Jörn Walter; Karl Nordström; Klaus Eberhardt; Dennis Renisch; Sainitin Donakonda; Percy Knolle; Dominik Soll; Stephan Grabbe; Natalie Garzorz-Stark; Kilian Eyerich; Tilo Biedermann; Dirk Baumjohann; Christina E. Zielinski

doi:10.1126/scitranslmed.aau0683

Research ArticleALLERGY

Sodium chloride is an ionic checkpoint for human T_H2 cells and shapes the atopic skin microenvironment

Julia Matthias¹,²,³,
Julia Maul⁴,
Rebecca Noster³,
Hanna Meinl¹,²,⁵,
Ying-Yin Chao¹,²,⁵,
Heiko Gerstenberg⁶,
Florian Jeschke⁶,
Gilles Gasparoni⁷,
Anna Welle⁷,
Jörn Walter⁷,
Karl Nordström⁷,
Klaus Eberhardt⁸,
Dennis Renisch⁸,
Sainitin Donakonda²,⁹,
Percy Knolle²,⁹,
Dominik Soll¹,²,
Stephan Grabbe¹⁰,
Natalie Garzorz-Stark¹¹,
Kilian Eyerich¹¹,
Tilo Biedermann¹¹,
Dirk Baumjohann ⁴ and
Christina E. Zielinski ¹,²,³,⁵,*

¹Institute of Virology, Technical University of Munich, 81675 Munich, Germany.
²German Center for Infection Research, Partner Site Munich, Munich, Germany.
³Department of Dermatology, Unit Cellular Immunoregulation, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
⁴Institute for Immunology, Biomedical Center, Ludwig-Maximilians-Universität München, 82152 Planegg-Martinsried, Germany.
⁵TranslaTUM, Technical University of Munich, 81675 Munich, Germany.
⁶ZWE FRM II, Technical University of Munich, 85748 Garching, Germany.
⁷Department of Genetics, University of Saarland, 66123 Saarbrücken, Germany.
⁸Institute for Nuclear Chemistry, Johannes Gutenberg-Universität Mainz and Helmholtz Institute Mainz, 55252 Mainz, Germany.
⁹Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, 81675 Munich, Germany.
¹⁰Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.
¹¹Department of Dermatology and Allergology, Technical University of Munich; Clinical Unit Allergology (EKA), Helmholtz Zentrum München; German Research Centre for Environmental Health GmbH, 80802 Munich, Germany.

↵*Corresponding author. Email: christina.zielinski{at}tum.de

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Science Translational Medicine 20 Feb 2019:
Vol. 11, Issue 480, eaau0683
DOI: 10.1126/scitranslmed.aau0683

Julia Matthias

Institute of Virology, Technical University of Munich, 81675 Munich, Germany.German Center for Infection Research, Partner Site Munich, Munich, Germany.Department of Dermatology, Unit Cellular Immunoregulation, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.

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Julia Maul

Institute for Immunology, Biomedical Center, Ludwig-Maximilians-Universität München, 82152 Planegg-Martinsried, Germany.

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Rebecca Noster

Department of Dermatology, Unit Cellular Immunoregulation, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.

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Hanna Meinl

Institute of Virology, Technical University of Munich, 81675 Munich, Germany.German Center for Infection Research, Partner Site Munich, Munich, Germany.TranslaTUM, Technical University of Munich, 81675 Munich, Germany.

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Ying-Yin Chao

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Heiko Gerstenberg

ZWE FRM II, Technical University of Munich, 85748 Garching, Germany.

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Florian Jeschke

ZWE FRM II, Technical University of Munich, 85748 Garching, Germany.

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Gilles Gasparoni

Department of Genetics, University of Saarland, 66123 Saarbrücken, Germany.

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Anna Welle

Department of Genetics, University of Saarland, 66123 Saarbrücken, Germany.

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Jörn Walter

Department of Genetics, University of Saarland, 66123 Saarbrücken, Germany.

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Karl Nordström

Department of Genetics, University of Saarland, 66123 Saarbrücken, Germany.

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Klaus Eberhardt

Institute for Nuclear Chemistry, Johannes Gutenberg-Universität Mainz and Helmholtz Institute Mainz, 55252 Mainz, Germany.

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Dennis Renisch

Institute for Nuclear Chemistry, Johannes Gutenberg-Universität Mainz and Helmholtz Institute Mainz, 55252 Mainz, Germany.

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Sainitin Donakonda

German Center for Infection Research, Partner Site Munich, Munich, Germany.Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, 81675 Munich, Germany.

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Percy Knolle

German Center for Infection Research, Partner Site Munich, Munich, Germany.Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, 81675 Munich, Germany.

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Dominik Soll

Institute of Virology, Technical University of Munich, 81675 Munich, Germany.German Center for Infection Research, Partner Site Munich, Munich, Germany.

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Stephan Grabbe

Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.

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Natalie Garzorz-Stark

Department of Dermatology and Allergology, Technical University of Munich; Clinical Unit Allergology (EKA), Helmholtz Zentrum München; German Research Centre for Environmental Health GmbH, 80802 Munich, Germany.

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Kilian Eyerich

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Tilo Biedermann

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Dirk Baumjohann

Institute for Immunology, Biomedical Center, Ludwig-Maximilians-Universität München, 82152 Planegg-Martinsried, Germany.

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Christina E. Zielinski

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For correspondence: christina.zielinski@tum.de

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Sodium chloride is an ionic checkpoint for human T_H2 cells and shapes the atopic skin microenvironment

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