Research ArticleALLERGY
Sodium chloride is an ionic checkpoint for human TH2 cells and shapes the atopic skin microenvironment
- View ORCID ProfileJulia Matthias1,2,3,
- View ORCID ProfileJulia Maul4,
- View ORCID ProfileRebecca Noster3,
- View ORCID ProfileHanna Meinl1,2,5,
- Ying-Yin Chao1,2,5,
- Heiko Gerstenberg6,
- Florian Jeschke6,
- View ORCID ProfileGilles Gasparoni7,
- Anna Welle7,
- Jörn Walter7,
- View ORCID ProfileKarl Nordström7,
- Klaus Eberhardt8,
- Dennis Renisch8,
- View ORCID ProfileSainitin Donakonda2,9,
- View ORCID ProfilePercy Knolle2,9,
- View ORCID ProfileDominik Soll1,2,
- Stephan Grabbe10,
- Natalie Garzorz-Stark11,
- Kilian Eyerich11,
- View ORCID ProfileTilo Biedermann11,
- View ORCID ProfileDirk Baumjohann4 and
- View ORCID ProfileChristina E. Zielinski1,2,3,5,*
- 1Institute of Virology, Technical University of Munich, 81675 Munich, Germany.
- 2German Center for Infection Research, Partner Site Munich, Munich, Germany.
- 3Department of Dermatology, Unit Cellular Immunoregulation, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
- 4Institute for Immunology, Biomedical Center, Ludwig-Maximilians-Universität München, 82152 Planegg-Martinsried, Germany.
- 5TranslaTUM, Technical University of Munich, 81675 Munich, Germany.
- 6ZWE FRM II, Technical University of Munich, 85748 Garching, Germany.
- 7Department of Genetics, University of Saarland, 66123 Saarbrücken, Germany.
- 8Institute for Nuclear Chemistry, Johannes Gutenberg-Universität Mainz and Helmholtz Institute Mainz, 55252 Mainz, Germany.
- 9Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, 81675 Munich, Germany.
- 10Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.
- 11Department of Dermatology and Allergology, Technical University of Munich; Clinical Unit Allergology (EKA), Helmholtz Zentrum München; German Research Centre for Environmental Health GmbH, 80802 Munich, Germany.
- ↵*Corresponding author. Email: christina.zielinski{at}tum.de
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Science Translational Medicine 20 Feb 2019:
Vol. 11, Issue 480, eaau0683
DOI: 10.1126/scitranslmed.aau0683
Vol. 11, Issue 480, eaau0683
DOI: 10.1126/scitranslmed.aau0683
Julia Matthias
1Institute of Virology, Technical University of Munich, 81675 Munich, Germany.
2German Center for Infection Research, Partner Site Munich, Munich, Germany.
3Department of Dermatology, Unit Cellular Immunoregulation, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Julia Maul
4Institute for Immunology, Biomedical Center, Ludwig-Maximilians-Universität München, 82152 Planegg-Martinsried, Germany.
Rebecca Noster
3Department of Dermatology, Unit Cellular Immunoregulation, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Hanna Meinl
1Institute of Virology, Technical University of Munich, 81675 Munich, Germany.
2German Center for Infection Research, Partner Site Munich, Munich, Germany.
5TranslaTUM, Technical University of Munich, 81675 Munich, Germany.
Ying-Yin Chao
1Institute of Virology, Technical University of Munich, 81675 Munich, Germany.
2German Center for Infection Research, Partner Site Munich, Munich, Germany.
5TranslaTUM, Technical University of Munich, 81675 Munich, Germany.
Heiko Gerstenberg
6ZWE FRM II, Technical University of Munich, 85748 Garching, Germany.
Florian Jeschke
6ZWE FRM II, Technical University of Munich, 85748 Garching, Germany.
Gilles Gasparoni
7Department of Genetics, University of Saarland, 66123 Saarbrücken, Germany.
Anna Welle
7Department of Genetics, University of Saarland, 66123 Saarbrücken, Germany.
Jörn Walter
7Department of Genetics, University of Saarland, 66123 Saarbrücken, Germany.
Karl Nordström
7Department of Genetics, University of Saarland, 66123 Saarbrücken, Germany.
Klaus Eberhardt
8Institute for Nuclear Chemistry, Johannes Gutenberg-Universität Mainz and Helmholtz Institute Mainz, 55252 Mainz, Germany.
Dennis Renisch
8Institute for Nuclear Chemistry, Johannes Gutenberg-Universität Mainz and Helmholtz Institute Mainz, 55252 Mainz, Germany.
Sainitin Donakonda
2German Center for Infection Research, Partner Site Munich, Munich, Germany.
9Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, 81675 Munich, Germany.
Percy Knolle
2German Center for Infection Research, Partner Site Munich, Munich, Germany.
9Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, 81675 Munich, Germany.
Dominik Soll
1Institute of Virology, Technical University of Munich, 81675 Munich, Germany.
2German Center for Infection Research, Partner Site Munich, Munich, Germany.
Stephan Grabbe
10Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.
Natalie Garzorz-Stark
11Department of Dermatology and Allergology, Technical University of Munich; Clinical Unit Allergology (EKA), Helmholtz Zentrum München; German Research Centre for Environmental Health GmbH, 80802 Munich, Germany.
Kilian Eyerich
11Department of Dermatology and Allergology, Technical University of Munich; Clinical Unit Allergology (EKA), Helmholtz Zentrum München; German Research Centre for Environmental Health GmbH, 80802 Munich, Germany.
Tilo Biedermann
11Department of Dermatology and Allergology, Technical University of Munich; Clinical Unit Allergology (EKA), Helmholtz Zentrum München; German Research Centre for Environmental Health GmbH, 80802 Munich, Germany.
Dirk Baumjohann
4Institute for Immunology, Biomedical Center, Ludwig-Maximilians-Universität München, 82152 Planegg-Martinsried, Germany.
Christina E. Zielinski
1Institute of Virology, Technical University of Munich, 81675 Munich, Germany.
2German Center for Infection Research, Partner Site Munich, Munich, Germany.
3Department of Dermatology, Unit Cellular Immunoregulation, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
5TranslaTUM, Technical University of Munich, 81675 Munich, Germany.
