Research ArticleALLERGY
Sodium chloride is an ionic checkpoint for human TH2 cells and shapes the atopic skin microenvironment
- Julia Matthias1,2,3,
- Julia Maul4,
- Rebecca Noster3,
- Hanna Meinl1,2,5,
- Ying-Yin Chao1,2,5,
- Heiko Gerstenberg6,
- Florian Jeschke6,
- Gilles Gasparoni7,
- Anna Welle7,
- Jörn Walter7,
- Karl Nordström7,
- Klaus Eberhardt8,
- Dennis Renisch8,
- Sainitin Donakonda2,9,
- Percy Knolle2,9,
- Dominik Soll1,2,
- Stephan Grabbe10,
- Natalie Garzorz-Stark11,
- Kilian Eyerich11,
- Tilo Biedermann11,
- Dirk Baumjohann4 and
- Christina E. Zielinski1,2,3,5,*
- 1Institute of Virology, Technical University of Munich, 81675 Munich, Germany.
- 2German Center for Infection Research, Partner Site Munich, Munich, Germany.
- 3Department of Dermatology, Unit Cellular Immunoregulation, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
- 4Institute for Immunology, Biomedical Center, Ludwig-Maximilians-Universität München, 82152 Planegg-Martinsried, Germany.
- 5TranslaTUM, Technical University of Munich, 81675 Munich, Germany.
- 6ZWE FRM II, Technical University of Munich, 85748 Garching, Germany.
- 7Department of Genetics, University of Saarland, 66123 Saarbrücken, Germany.
- 8Institute for Nuclear Chemistry, Johannes Gutenberg-Universität Mainz and Helmholtz Institute Mainz, 55252 Mainz, Germany.
- 9Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, 81675 Munich, Germany.
- 10Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.
- 11Department of Dermatology and Allergology, Technical University of Munich; Clinical Unit Allergology (EKA), Helmholtz Zentrum München; German Research Centre for Environmental Health GmbH, 80802 Munich, Germany.
- ↵*Corresponding author. Email: christina.zielinski{at}tum.de
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Science Translational Medicine 20 Feb 2019:
Vol. 11, Issue 480, eaau0683
DOI: 10.1126/scitranslmed.aau0683
Vol. 11, Issue 480, eaau0683
DOI: 10.1126/scitranslmed.aau0683
Julia Matthias
Institute of Virology, Technical University of Munich, 81675 Munich, Germany.
German Center for Infection Research, Partner Site Munich, Munich, Germany.
Department of Dermatology, Unit Cellular Immunoregulation, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Julia Maul
Institute for Immunology, Biomedical Center, Ludwig-Maximilians-Universität München, 82152 Planegg-Martinsried, Germany.
Rebecca Noster
Department of Dermatology, Unit Cellular Immunoregulation, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Hanna Meinl
Institute of Virology, Technical University of Munich, 81675 Munich, Germany.
German Center for Infection Research, Partner Site Munich, Munich, Germany.
TranslaTUM, Technical University of Munich, 81675 Munich, Germany.
Ying-Yin Chao
Institute of Virology, Technical University of Munich, 81675 Munich, Germany.
German Center for Infection Research, Partner Site Munich, Munich, Germany.
TranslaTUM, Technical University of Munich, 81675 Munich, Germany.
Heiko Gerstenberg
ZWE FRM II, Technical University of Munich, 85748 Garching, Germany.
Florian Jeschke
ZWE FRM II, Technical University of Munich, 85748 Garching, Germany.
Gilles Gasparoni
Department of Genetics, University of Saarland, 66123 Saarbrücken, Germany.
Anna Welle
Department of Genetics, University of Saarland, 66123 Saarbrücken, Germany.
Jörn Walter
Department of Genetics, University of Saarland, 66123 Saarbrücken, Germany.
Karl Nordström
Department of Genetics, University of Saarland, 66123 Saarbrücken, Germany.
Klaus Eberhardt
Institute for Nuclear Chemistry, Johannes Gutenberg-Universität Mainz and Helmholtz Institute Mainz, 55252 Mainz, Germany.
Dennis Renisch
Institute for Nuclear Chemistry, Johannes Gutenberg-Universität Mainz and Helmholtz Institute Mainz, 55252 Mainz, Germany.
Sainitin Donakonda
German Center for Infection Research, Partner Site Munich, Munich, Germany.
Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, 81675 Munich, Germany.
Percy Knolle
German Center for Infection Research, Partner Site Munich, Munich, Germany.
Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, 81675 Munich, Germany.
Dominik Soll
Institute of Virology, Technical University of Munich, 81675 Munich, Germany.
German Center for Infection Research, Partner Site Munich, Munich, Germany.
Stephan Grabbe
Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.
Natalie Garzorz-Stark
Department of Dermatology and Allergology, Technical University of Munich; Clinical Unit Allergology (EKA), Helmholtz Zentrum München; German Research Centre for Environmental Health GmbH, 80802 Munich, Germany.
Kilian Eyerich
Department of Dermatology and Allergology, Technical University of Munich; Clinical Unit Allergology (EKA), Helmholtz Zentrum München; German Research Centre for Environmental Health GmbH, 80802 Munich, Germany.
Tilo Biedermann
Department of Dermatology and Allergology, Technical University of Munich; Clinical Unit Allergology (EKA), Helmholtz Zentrum München; German Research Centre for Environmental Health GmbH, 80802 Munich, Germany.
Dirk Baumjohann
Institute for Immunology, Biomedical Center, Ludwig-Maximilians-Universität München, 82152 Planegg-Martinsried, Germany.
Christina E. Zielinski
Institute of Virology, Technical University of Munich, 81675 Munich, Germany.
German Center for Infection Research, Partner Site Munich, Munich, Germany.
Department of Dermatology, Unit Cellular Immunoregulation, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
TranslaTUM, Technical University of Munich, 81675 Munich, Germany.
