Research ArticleTHROMBOSIS
Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models
- Anne-Laure Papa1,2,*,
- Amanda Jiang3,
- Netanel Korin1,†,
- Michelle B. Chen4,‡,
- Erin T. Langan5,
- Anna Waterhouse1,§,||,
- Emma Nash1,
- Jildaz Caroff5,
- Amanda Graveline1,
- Andyna Vernet1,
- Akiko Mammoto3,¶,
- Tadanori Mammoto3,#,
- Abhishek Jain1,**,
- Roger D. Kamm4,6,
- Matthew J. Gounis5 and
- Donald E. Ingber1,3,7,*
- 1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
- 2Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
- 3Vascular Biology Program and Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
- 4Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 5New England Center for Stroke Research, Department of Radiology, University of Massachusetts, Worcester, MA 01655, USA.
- 6Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 7Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA 02138, USA.
- ↵*Corresponding author. Email: don.ingber{at}wyss.harvard.edu (D.E.I.); alpapa{at}gwu.edu (A.-L.P.)
↵† Present address: Department of Biomedical Engineering, Technion–Israel Institute of Technology, Haifa 32000, Israel.
↵‡ Present address: Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
↵§ Present address: Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia.
↵|| Present address: Heart Research Institute, Newtown, NSW 2042, Australia.
↵¶ Present address: Department of Pediatrics, Medical College of Wisconsin, 8701 W Watertown Plank Road, Milwaukee, WI 53226, USA.
↵# Present address: Department of Radiology, Medical College of Wisconsin, 8701 W Watertown Plank Road, Milwaukee, WI 53226, USA.
↵** Present address: Department of Biomedical Engineering, Texas A&M College of Engineering, Emerging Technologies Building, 101 Bizzell Street, College Station, TX 77843, USA.
See allHide authors and affiliations
Science Translational Medicine 13 Feb 2019:
Vol. 11, Issue 479, eaau5898
DOI: 10.1126/scitranslmed.aau5898
