Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models

Anne-Laure Papa; Amanda Jiang; Netanel Korin; Michelle B. Chen; Erin T. Langan; Anna Waterhouse; Emma Nash; Jildaz Caroff; Amanda Graveline; Andyna Vernet; Akiko Mammoto; Tadanori Mammoto; Abhishek Jain; Roger D. Kamm; Matthew J. Gounis; Donald E. Ingber

doi:10.1126/scitranslmed.aau5898

Research ArticleTHROMBOSIS

Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models

View ORCID ProfileAnne-Laure Papa ¹,²,*,
View ORCID ProfileAmanda Jiang³,
View ORCID ProfileNetanel Korin¹,†,
Michelle B. Chen⁴,‡,
View ORCID ProfileErin T. Langan⁵,
View ORCID ProfileAnna Waterhouse¹,§,||,
View ORCID ProfileEmma Nash¹,
View ORCID ProfileJildaz Caroff⁵,
View ORCID ProfileAmanda Graveline¹,
Andyna Vernet¹,
Akiko Mammoto³,¶,
Tadanori Mammoto³,#,
View ORCID ProfileAbhishek Jain¹,**,
View ORCID ProfileRoger D. Kamm ⁴,⁶,
View ORCID ProfileMatthew J. Gounis⁵ and
View ORCID ProfileDonald E. Ingber ¹,³,⁷,*

¹Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
²Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
³Vascular Biology Program and Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
⁴Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁵New England Center for Stroke Research, Department of Radiology, University of Massachusetts, Worcester, MA 01655, USA.
⁶Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁷Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA 02138, USA.

↵*Corresponding author. Email: don.ingber{at}wyss.harvard.edu (D.E.I.); alpapa{at}gwu.edu (A.-L.P.)

↵† Present address: Department of Biomedical Engineering, Technion–Israel Institute of Technology, Haifa 32000, Israel.
↵‡ Present address: Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
↵§ Present address: Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia.
↵|| Present address: Heart Research Institute, Newtown, NSW 2042, Australia.
↵¶ Present address: Department of Pediatrics, Medical College of Wisconsin, 8701 W Watertown Plank Road, Milwaukee, WI 53226, USA.
↵# Present address: Department of Radiology, Medical College of Wisconsin, 8701 W Watertown Plank Road, Milwaukee, WI 53226, USA.
↵** Present address: Department of Biomedical Engineering, Texas A&M College of Engineering, Emerging Technologies Building, 101 Bizzell Street, College Station, TX 77843, USA.

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Science Translational Medicine 13 Feb 2019:
Vol. 11, Issue 479, eaau5898
DOI: 10.1126/scitranslmed.aau5898

Anne-Laure Papa

1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

2Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.

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For correspondence: don.ingber@wyss.harvard.edu alpapa@gwu.edu

Amanda Jiang

3Vascular Biology Program and Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

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Netanel Korin

1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

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Michelle B. Chen

4Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Erin T. Langan

5New England Center for Stroke Research, Department of Radiology, University of Massachusetts, Worcester, MA 01655, USA.

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Anna Waterhouse

1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

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Emma Nash

1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

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Jildaz Caroff

5New England Center for Stroke Research, Department of Radiology, University of Massachusetts, Worcester, MA 01655, USA.

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Amanda Graveline

1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

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Andyna Vernet

1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

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Akiko Mammoto

3Vascular Biology Program and Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

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Tadanori Mammoto

3Vascular Biology Program and Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

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Abhishek Jain

1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

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Roger D. Kamm

4Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

6Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Matthew J. Gounis

5New England Center for Stroke Research, Department of Radiology, University of Massachusetts, Worcester, MA 01655, USA.

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Donald E. Ingber

1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

3Vascular Biology Program and Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

7Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA 02138, USA.

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For correspondence: don.ingber@wyss.harvard.edu alpapa@gwu.edu

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Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models

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