Research ArticleTHROMBOSIS

Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models

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Science Translational Medicine  13 Feb 2019:
Vol. 11, Issue 479, eaau5898
DOI: 10.1126/scitranslmed.aau5898

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Deceiving platelets

Platelets play a key role in homeostasis; however, platelet activation also contributes to several disorders, including cardiac diseases and cancer. Platelet inhibitors have been developed; however, slow reversal time increases the risk of adverse events. Now, Papa et al. produced rapidly reversible drug-free antiplatelet agents by modifying human platelets. The modified platelets, called platelet decoys, prevented thrombus formation in rabbits. Moreover, platelet decoys decreased metastasis formation in a mouse model of breast cancer by preventing cancer cell extravasation. The results suggest that platelet decoys might be an effective rapidly reversible therapy for treating thrombosis and possibly metastasis formation.

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